bmp 4

Expression system: E. coli
Length: 294-409, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 293-408, Full Length of Mature Protein
Activity: Not Tested

BMP-4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P21275.

Expression system: E. coli
Length: 293-408 (mutation), Full Length of Mature Protein
Activity: Cell Activity

Cerberus 1 CER1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 29.6 kDa and the accession number is AAH69371.1.

CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of monkeys infected with simian immunodeficiency virus, and of rats subjected to L5 L6 spinal nerve ligation, sciatic nerve chronic constriction, and subcutaneous injection of complete Freund's adjuvant. Increased CGRP-IL was also detected in epidermal keratinocytes of transgenic mice with keratin-14 promoter driven overexpression of noggin, an antagonist to BMP-4 signaling. CGPR dilates a variety of vessels including the coronary, cerebral and systemic vasculature.

Expression system: HEK293 Cells
Length: 24-211, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 382-501, Full Length of Mature Protein
Activity: Cell Activity

Expression system: Baculovirus Insect Cells
Length: 1-425, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 382-501, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 382-501, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 2-467, Full Length of Mature Protein
Activity: Not Tested

Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.