biliary

7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and suppresses the production of endogenous bile acid and the secretion of biliary cholesterol.

Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.

Allolithocholic acid (allo-LCA) is found in the urine of infants with biliary atresia and is often excreted as sulfate-conjugated bile acids.Allolithocholic acid promotes intestinal and hepatic metabolism.

Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, influences bile salt and biliary lipid secretion in rats.

Tauroursocholic acid (TUCA) is the taurine-conjugated derivative of ursocholic acid and serves as the 7β-hydroxy epimer of taurocholic acid (TCA). Unlike TCA, TUCA does not inhibit HMG-CoA reductase or the cytochrome P450 (CYP) isoform CYP7A1, also known as cholesterol 7α-hydroxylase. Elevated bile levels of TUCA are observed in patients with biliary tract cancer compared to those with benign biliary conditions.