a-66

A66 is a specific and effective p110α inhibitor(IC50=32 nM).

TRIA-662 (Nicotinamide Chloromethylate) is a niacin metabolite excreted via the urinary system.

β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.

SH-E4A-66 is a C2-COUPLr (COvalent Protein Ligators) featuring a carbazole skeleton, which does not include heterogeneous cysteine-reactive warheads such as acrylamide and chloroacetamide. This compound effectively couples with EML4-ALK (EC50=1.5 μM) and inhibits the kinase activity of EML4-ALK (IC50=2.3 µM).

PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.

Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.

A 69024 is a highly selective antagonist of dopamine D-1 receptor.

LL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

(R)-1-Boc-3-(hydroxymethyl)piperazine ,with CAS No. 278788-66-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (R)-1-Boc-3-(hydroxymethyl)piperazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-(Trifluoromethyl)nicotinic acid ,with CAS No. 158063-66-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(Trifluoromethyl)nicotinic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Chloro-4-fluoroacetophenone ,with CAS No. 2923-66-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Chloro-4-fluoroacetophenone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Benzylthiomorpholine 1,1-dioxide ,with CAS No. 26475-66-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Benzylthiomorpholine 1,1-dioxide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3,4-(Methylenedioxy)aniline ,with CAS No. 14268-66-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3,4-(Methylenedioxy)aniline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Azacyclooctanone ,with CAS No. 673-66-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Azacyclooctanone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-(4-methoxyphenyl)acetamide ,with CAS No. 51-66-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-(4-methoxyphenyl)acetamide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-(3-HYDROXYPROPYL)BENZIMIDAZOLE, with CAS No. 2403-66-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-(3-HYDROXYPROPYL)BENZIMIDAZOLE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2,6-Diethylaniline ,with CAS No. 579-66-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,6-Diethylaniline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-(Pyridin-3-yl)pyrimidin-2-amine ,with CAS No. 66521-66-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(Pyridin-3-yl)pyrimidin-2-amine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

cis-Hexahydrophthalimide ,with CAS No. 7506-66-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. cis-Hexahydrophthalimide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a toxic secondary bile acid, They were FXR antagonists (IC50=0.7, 1.4 μM), EphA2 antagonists (IC50=48, 66 μM) and EphB4 antagonists (IC50=141 μM). Lithocholic acid can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is a cleanser that dissolves fat for absorption and is itself absorbed.

1,2-Diphenoxyethane is composed of two phenoxy groups connected by ethane and is widely used in biochemical experiments and drug synthesis research.

Cyclopropyl diphenyl carbinol ,with CAS No. 5785-66-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Cyclopropyl diphenyl carbinol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-methyl-n-(2-thien-2-ylbenzyl)amine ,with CAS No. 852180-66-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-methyl-n-(2-thien-2-ylbenzyl)amine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1H-imidazole, 4,5-dihydro-2-(methylthio)-1-(phenylmethyl)-, hydriodide (1:1) ,with CAS No. 550347-66-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1H-imidazole, 4,5-dihydro-2-(methylthio)-1-(phenylmethyl)-, hydriodide (1:1) provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.