a-66

A66 is a specific and effective p110α inhibitor(IC50=32 nM).

TRIA-662 (Nicotinamide Chloromethylate) is a niacin metabolite excreted via the urinary system.

PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.

β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.

SH-E4A-66 is a C2-COUPLr (COvalent Protein Ligators) featuring a carbazole skeleton, which does not include heterogeneous cysteine-reactive warheads such as acrylamide and chloroacetamide. This compound effectively couples with EML4-ALK (EC50=1.5 μM) and inhibits the kinase activity of EML4-ALK (IC50=2.3 µM).

LL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

4-Chlorophenylacetic acid is a useful organic compound for research related to life sciences. The catalog number is T65823 and the CAS number is 1878-66-6.

COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor[3]. COR659 (0, 2.5, 5 and 10 mg kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats[1].COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats[2]. Animal Model: Male sP and Wistar rats[1]. [1]. Paola Maccioni, et al. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA B and cannabinoid CB 1 receptors. Psychopharmacology (Berl). 2017 Sep;234(17):2525-2543. [2]. Francesca Ferlenghi, et al. The GABA B receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Eur J Pharm Sci. 2020 Dec 1;155:105544. [3]. Paola Maccioni, et al. Anti-addictive properties of COR659 - Additional pharmacological evidence and comparison with a series of novel analogues. Alcohol. 2019 Mar;75:55-66.

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

BRD0705 is a potent, orally active GSK3α inhibitor with high selectivity (IC50: 66 nM; Kd: 4.8 μM), demonstrating an 8-fold higher selectivity for GSK3α compared to GSK3β (IC50: 515 nM).

BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705, a GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM, used in acute myeloid leukemia [AML] studies.

Isonerylgeraniol-18-oic acid is a useful organic compound for research related to life sciences. The catalog number is T123834 and the CAS number is 97208-66-7.

Teuscorodol is a useful organic compound for research related to life sciences. The catalog number is T124087 and the CAS number is 85563-66-2.

Coumarsabin is a useful organic compound for research related to life sciences. The catalog number is T124179 and the CAS number is 81421-66-1.

Camphans?ure (+)- is a useful organic compound for research related to life sciences. The catalog number is T124427 and the CAS number is 67111-66-4.

5,6,7-Trihydroxy-4'-methoxyflavone is a useful organic compound for research related to life sciences. The catalog number is T124460 and the CAS number is 6563-66-2.

Thevetin A is a useful organic compound for research related to life sciences. The catalog number is T124930 and the CAS number is 37933-66-7.

7-Hydroxy-6-methoxydihydroflavonol is a useful organic compound for research related to life sciences. The catalog number is T125011 and the CAS number is 34050-66-3.

1,3-Diacetoxy-4,6,12-tetradecatriene-8,10-diyne is a useful organic compound for research related to life sciences. The catalog number is T125101 and the CAS number is 29576-66-7.

Antibiotic WB is a useful organic compound for research related to life sciences. The catalog number is T125208 and the CAS number is 247919-66-0.

Syringolin B is a useful organic compound for research related to life sciences. The catalog number is T125254 and the CAS number is 235096-66-9.

Lonfuranacid B is a useful organic compound for research related to life sciences. The catalog number is T125349 and the CAS number is 2131269-66-2.

Pterodontoside E is a natural product that can be used as a reference standard. The CAS number of Pterodontoside E is 186374-66-3.

CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1; IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively).