Citharexylum

Syrosingopine is a dual inhibitor of MCT1 and MCT4, 60 times more potent against MCT4, preventing lactate and H+ efflux. Syrosingopine is an orally available antihypertensive drug with potential for cancer research in combination with metformin.

Reserpine (Serpalan) is an alkaloid isolated from the root of Rauwolfia serpentina. As an inhibitor of vesicular monoamine transporter 2 (VMAT2), it suppresses the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral nerve terminals. It has antihypertensive and antipsychotic effects and can be used to induce gastric ulcer and depression models.

Picrinine is an akuammiline alkaloid extracted from the leaves of Alstonia scholaris. It exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase.

Reserpine hydrochloride is the salt form of Reserpine and acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2). It blocks the uptake of norepinephrine into storage vesicles, leading to the depletion of catecholamines and serotonin at central and peripheral nerve terminals. It has antihypertensive and antipsychotic properties and is commonly used to induce models of gastric ulcer and depression.

Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations.

2,6-Dimethylbenzoquinone (2,6-Dimethylquinone) is a benzoquinone, a chemical compound found in Rauvolfia vomitoria and in Tibouchina pulchra.At physiological concentrations 2, 6-Dimethoxy-p-benzoquinone is an antibacterial substance

Methyl levulinate is a green reagent derived from biomass, widely used in biochemical experiments and drug synthesis research.

Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose uptake by C2C12 cells.Serpentine increases the expression of GSK-3β mRNA in muscle tissues, which enhances glucose uptake.Serpentine also increases glucose production and hepatic gluconeogenesis.Serpentine has a significant effect on glucagon secretion and hepatic gluconeogenesis. Serpentine significantly increased glucagon secretion and hepatic gluconeogenesis. In high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice, Serpentine significantly prolonged insulin hypoglycemia, significantly decreased exogenous insulin use, and inhibited endogenous insulin secretion.

Isorauhimbine is an alkaloid derived from R. serpentina with anticancer, anti-inflammatory and antimicrobial activities and is used in the treatment of cardiovascular diseases such as hypertension, arrhythmia and angina pectoris.

3-Hydroxysarpagine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2953 and the CAS number is 857297-90-6. 3-Hydroxysarpagine can be used as a reference standard.

Rauvovertine C shows cytotoxicity in vitro against human tumor cell lines.

Macusine B is a dual inhibitor, has almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).

A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.

Tombozine is a natural product from Rauvolfia yunnanensis.

Rauvotetraphylline A is a natural product from Rauvolfia tetraphylla.

Vellosimine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN5224 and the CAS number is 6874-98-2. Vellosimine can be used as a reference standard.

Spegatrine is a natural product from Rauvolfia verticillata.

10-Hydroxy-16-epiaffinine, a natural product of Rauvolfia (Apocynaceae), has the catalog number TN6039 and the CAS number 82513-70-0. It can be used as a reference standard.

Antirhine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN3425 and the CAS number is 16049-28-8. Antirhine can be used as a reference standard.

Perakine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2051 and the CAS number is 4382-56-3. Perakine can be used as a reference standard.

Methyl sinapate can increase the frequency of cells with chromosome aberrations in the CHO K-1 cells treated with MMC, 4NQO or UV.

Rauvoyunine B is a natural product from Rauvolfia yunnanensis.

Yohimbic acid is a natural derivative of Yohimbine exhibiting weak inhibition of topoisomerase 1/2 at the μM level.

Rauvotetraphylline C is a natural product from Rauvolfia tetraphylla.