Verbenaceae

Syrosingopine is a dual inhibitor of MCT1 and MCT4, 60 times more potent against MCT4, preventing lactate and H+ efflux. Syrosingopine is an orally available antihypertensive drug with potential for cancer research in combination with metformin.

Reserpine (Serpalan) is an alkaloid isolated from the root of Rauwolfia serpentina. As an inhibitor of vesicular monoamine transporter 2 (VMAT2), it suppresses the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral nerve terminals. It has antihypertensive and antipsychotic effects and can be used to induce gastric ulcer and depression models.

Brandioside (2'-Acetylpoliumoside), a phenylpropanoid glycoside obtainable from Callicarpa dichotoma Raeuschel, Verbenaceae, has antioxidant activity, attenuates glutamate-induced neurotoxicity, and can be used in the study of diabetes mellitus.

Picrinine is an akuammiline alkaloid extracted from the leaves of Alstonia scholaris. It exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase.

Reserpine hydrochloride is the salt form of Reserpine and acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2). It blocks the uptake of norepinephrine into storage vesicles, leading to the depletion of catecholamines and serotonin at central and peripheral nerve terminals. It has antihypertensive and antipsychotic properties and is commonly used to induce models of gastric ulcer and depression.

Hexyl 2-Methylbutanoate is an ester compound widely used in biochemical experiments and drug synthesis research.

Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations.

Hastatoside and verbenalin are major sleep-promoting components of V. officinalis. Hastatoside has anti-inflammatory activity.

2,6-Dimethylbenzoquinone (2,6-Dimethylquinone) is a benzoquinone, a chemical compound found in Rauvolfia vomitoria and in Tibouchina pulchra.At physiological concentrations 2, 6-Dimethoxy-p-benzoquinone is an antibacterial substance

(-)-Verbenone is a naturally occurring terpene found in the leaves of Suregada zanzibariensis Verdc.Verbenone has anti-aggregation pheromone effects and interrupts the attraction of bark beetles to its aggregation pheromone.

Coumaran (2,3-Dihydrobenzofuran), an acetylcholinesterase (AChE) inhibitor isolated from the leaves of L. camara, can be used as a biopesticide and belongs to the class of 1-benzofurans as the 2,3-dihydro derivative of benzofuran with a role as a metabolite.

Methyl levulinate is a green reagent derived from biomass, widely used in biochemical experiments and drug synthesis research.

5,6,7-Trihydroxy-4'-methoxyflavone is an antioxidant natural product exhibiting an IC₅₀ of 25.29 μM in DPPH radical scavenging activity assays on PC12 cells.

Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose uptake by C2C12 cells.Serpentine increases the expression of GSK-3β mRNA in muscle tissues, which enhances glucose uptake.Serpentine also increases glucose production and hepatic gluconeogenesis.Serpentine has a significant effect on glucagon secretion and hepatic gluconeogenesis. Serpentine significantly increased glucagon secretion and hepatic gluconeogenesis. In high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice, Serpentine significantly prolonged insulin hypoglycemia, significantly decreased exogenous insulin use, and inhibited endogenous insulin secretion.

Isorauhimbine is an alkaloid derived from R. serpentina with anticancer, anti-inflammatory and antimicrobial activities and is used in the treatment of cardiovascular diseases such as hypertension, arrhythmia and angina pectoris.

3-Hydroxysarpagine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2953 and the CAS number is 857297-90-6. 3-Hydroxysarpagine can be used as a reference standard.

Cyclohexylacetic acid is an important aliphatic carboxylic acid organic reagent. Cyclohexylacetic acid serves as a key intermediate in organic synthesis for the production of antiepileptic drugs, anti-inflammatory drugs, herbicides, and other compounds. Cyclohexylacetic acid can also be used as a culture medium additive, a buffer component, or a metabolic probe.

Desmethoxycentaureidin shows high inhibitory activity against HeLa cell growth (GI50 9 microM).

Rauvovertine C shows cytotoxicity in vitro against human tumor cell lines.

Macusine B is a dual inhibitor, has almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).

A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity.

Tombozine is a natural product from Rauvolfia yunnanensis.

Rauvotetraphylline A is a natural product from Rauvolfia tetraphylla.

Vellosimine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN5224 and the CAS number is 6874-98-2. Vellosimine can be used as a reference standard.