3D Bioprinting

LAP is a highly efficient and biocompatible radical photoinitiator used to initiate radical chain polymerisation and synthesise polymeric materials under light irradiation. The primary wavelength for light absorption and polymerisation initiation is 405 nm. LAP concentrations ≥3.4 mmol/L and the radicals it generates exhibit cytotoxicity towards M-1 mouse renal collecting duct cells.

Elastin, pig is a matrix protein abundantly present in the extracellular matrix, characterised by insolubility, amorphous structure, and extensive cross-linking. It provides organs and tissues with tensile and retractive capabilities and exhibits resistance to various proteases except elastase, commonly used as a biomaterial for tissue repair.

GelMA (Gelatin Methacryloyl), with a methacrylation degree of 90%, is a derivative obtained from the reaction of gelatin with chitin anhydride (methacrylic anhydride, MA). The hydrogel formed by Gelatin Methacryloyl exhibits excellent biocompatibility and biodegradability, along with light cross-linking capability and adjustable physical properties. Under the influence of the photoinitiator LAP (HY-44076), GelMA, 90% methacrylation, self-assembles into fibrous hydrogels targeting bioactive adhesion sites, providing inherent support and biodegradation activity to tissue cells. Its applications include cell culture, biological 3D printing, tissue engineering, drug delivery, and biosensor development.

TPO-L is a photoinitiator used in 3D printing resins, facilitating two-photon induced polymerization. The two-photon absorption cross-section spectrum of Lucirin TPO-L exhibits a peak of 1.2 GM at 610 nm. Although the two-photon absorption cross-section is relatively small, Lucirin TPO-L demonstrates a high polymerization quantum yield.

2-[2-(2-ethoxyethoxy)ethoxy]ethan-1-ol (Tri(ethylene glycol) monoethyl ether) is an organic solvent with high solubility and coupling properties, which can be used as a chemical synthesis intermediate for the preparation of ester derivatives, and is mainly used as a high-boiling solvent for paints, inks, dyes and resins.

Silk fibroin, suitable for cell culture, is a widely used natural biopolymer ideal for cell culture. [Silk fibroin] serves as a scaffold material that meets specific requirements for biocompatibility, biodegradability, and tissue specificity.

GelMA (Gelatin Methacryloyl), with 90% methacrylation and green fluorescence, is a modification of gelatin achieved by grafting fluorescent molecules onto the polymer. Green Fluorescent Gelatin Methacryloyl acts as a scaffold beneficial for creating tissue analogs ranging from the vascular system to cartilage and bone, promoting cell proliferation and diffusion. In the presence of the photoinitiator LAP, GelMA self-assembles into fibrous hydrogels that target bioactive adhesion sites, providing essential support and biodegradability for tissue cells. Applications encompass cell culture, bio 3D printing, tissue engineering, among others.

Polyethylene glycol dimethyl ether (MW=2000) is a polyethylene glycol derivative that can be used in the preparation of rigid gel electrolytes.

Polyethylene glycol dimethyl ether (MW=250) is a polyethylene glycol derivative utilized in the preparation of rigid gel electrolytes.

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 2000) is a derivative of polyethylene glycol, which is utilized in applications such as bioconjugation, drug delivery, PEG hydrogels, crosslinking agents, and surface functionalization.

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 5000) is a derivative of polyethylene glycol, applicable in bioconjugation, drug delivery, PEG hydrogels, crosslinking agents, and surface functionalization.

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 3400) is a derivative of polyethylene glycol, suitable for use in bioconjugation, drug delivery, PEG hydrogels, cross-linkers, and surface functionalization.

NH2-PEG-COOH (Mn 2000) is a bifunctional cross-linker suitable for synthesizing PEG hydrogels.

PEG tosylate (MW 900) is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Poly(ethylene glycol) diacrylate (MW 1500) [PEGDA (MW 1500)] is a derivative of polyethylene glycol. It is utilized in the formation of cross-linked polymers.

Poly(ethylene glycol) diacrylate (MW 575), with MEHQ as an inhibitor, is a derivative of polyethylene glycol. This compound is utilized to create cross-linked polymers.

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid (Mn 1000) is a derivative of polyethylene glycol. It is applicable in bioconjugation, drug delivery, PEG hydrogels, as a cross-linking agent, and for surface functionalization.

NH2-PEG-COOH (Mn 1100) is a bifunctional crosslinker utilized in the synthesis of PEG hydrogels.

NH₂–PEG–COOH (Mn 3500) is a bifunctional crosslinker suitable for synthesising PEG hydrogels.

HS-PEG-NH2 (Mn 3500) is a bifunctional crosslinker utilized in the synthesis of PEG hydrogels.

Poly(ethylene glycol) dibenzoate (MW 410) is a derivative of polyethylene glycol (PEG).

Acrylate-PEG-NHS (MW 3500) is a photoreactive PEG compound that undergoes crosslinking when exposed to ultraviolet light, making it suitable for synthesizing PEG hydrogels.

Biotin-PEG-NH2 (Mn 5300) can be utilized in the biotinylation of polymer worm micelles to facilitate targeted delivery and drug transport into cells.

Silk Fibroin Methacryloyl (FibMA) is a methacryloyl-modified silk protein known for its excellent biocompatibility, stable mechanical properties, and good processability, making it an ideal substrate for multifunctional microneedle (MN) patches. MN patches crafted from Silk Fibroin Methacryloyl demonstrate impressive biocompatibility, drug release, angiogenesis promotion, antioxidant, and antibacterial properties, depending on the specific drug encapsulated. The substance requires self-assembly into fibrous hydrogels under the influence of the photoinitiator LAP (HY-44076), targeting bioactive adhesion sites for inherent tissue support and biodegradation activity. Applications include cell culture, bio-3D printing, and tissue engineering.