Heart Disease Modeling

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Cardiovascular System Disease Modeling

Heart Disease Modeling

(7)

Hyperlipidemia Modeling

(3)

Hypertension Modeling

(10)

(2)

Thrombolysis Modeling

(2)

Heart disease encompasses a variety of conditions including myocardial infarction, heart failure, cardiac hypertrophy, and arrhythmias. Animal models such as left anterior descending (LAD) coronary artery ligation, isoproterenol induction, pressure overload, and cardiotoxic drug administration are commonly used to investigate mechanisms of myocardial injury, electrophysiological disturbances, and to evaluate novel cardioprotective therapies.

Norepinephrine

T704451-41-2

Norepinephrine is an alkaloid neurotransmitter and an effective adrenergic receptor (AR) agonist that activates α1, α2, and β1 receptors. It is commonly used as a vasoactive agent for the treatment of shock and can also be used to induce cardiomyopathy models.

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Doxorubicin

T145623214-92-8

Doxorubicin (Adriamycin) is a fluorescent anthracycline antitumor antibiotic that inhibits Topoisomerase I II, induces apoptosis and autophagy, downregulates the AMPK signaling pathway, and is commonly used in cancer chemotherapy as well as in models of nephritis and heart failure.

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Norepinephrine bitartrate monohydrate

T1064108341-18-0

Norepinephrine bitartrate monohydrate is an effective adrenergic receptor (AR) agonist that directly activates α1, α2, and β1 receptors, and is commonly used to induce cardiomyopathy models.

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Trimethylamine N-oxide

T412451184-78-7

Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite derived from dietary choline, betaine, and carnitine. It induces inflammation by activating the ROS NLRP3 inflammasome and promotes fibroblast differentiation through the activation of the TGF-β Smad2 signaling pathway. TMAO is commonly used to induce cardiac fibrosis models.

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Trimethylamine N-oxide dihydrate

T524762637-93-8

Trimethylamine N-oxide dihydrate (TMANO dihydrate) is a gut microbiota-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS NLRP3 inflammasome and promotes fibroblast differentiation and cardiac fibrosis via the TGF-β Smad2 signaling pathway. TMANO dihydrate can be used to establish models of cardiac hypertrophy and cardiac fibrosis.

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Noradrenaline tartrate

T2017351-40-1

Noradrenaline tartrate is an effective adrenergic receptor agonist that activates α1, α2, and β1 receptors. It is a precursor of epinephrine and serves as the principal neurotransmitter of most postganglionic sympathetic fibers and the diffuse projection system in the brain originating from the locus coeruleus, and can be used to establish cardiomyopathy models.

35 days

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