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Cardiovascular System Disease Modeling Cardiovascular System Disease ModelingHeart Disease Modeling
Heart disease encompasses a variety of conditions including myocardial infarction, heart failure, cardiac hypertrophy, and arrhythmias. Animal models such as left anterior descending (LAD) coronary artery ligation, isoproterenol induction, pressure overload, and cardiotoxic drug administration are commonly used to investigate mechanisms of myocardial injury, electrophysiological disturbances, and to evaluate novel cardioprotective therapies.
norepinephrine
Cited
T704451-41-2
Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumour cells.
- $41
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CitedNorepinephrine bitartrate monohydrate
T1064108341-18-0
Norepinephrine bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
- $33
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Trimethylamine N-oxide
T412451184-78-7
Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging effects of urea.Trimethylamine N-oxide induces inflammation through activation of ROS NLRP3 inflammasomes, which can induce fibroblast differentiation and cardiac fibrosis.
- $29
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Trimethylamine N-oxide dihydrate
T524762637-93-8
Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.
- $41
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Doxorubicin Cited
T145623214-92-8
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
- $54
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CitedNoradrenaline tartrate
T2017351-40-1
Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus.
- TBD
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Norepinephrine hydrochloride
T60245329-56-6
Norepinephrine hydrochloride (Levarterenol hydrochloride) is a β1 -selective agonist of the adrenergic receptor with EC 50 of 5.37 μM [1].
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