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Wikimole

"Wikimole" refers to our "Molecule of the Week" program. Each week, TargetMol spotlights 1-2 star molecules, highlighting either our best-selling products or those from trending research fields. Each Wikimole product comes with a special discount—20% off for an entire month from its launch date on our website.

FilterHome Wikimole
    Mdivi-1
    Mitochondrial division inhibitor 1
    T1907338967-87-6
    Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.
    • $39
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    TargetMol | Inhibitor Hot
    Sorafenib
    Bay 43-9006
    T0093L284461-73-0
    Sorafenib (Bay 43-9006) is a multikinase inhibitor that targets Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. It exhibits antitumor properties and can induce autophagy, apoptosis, and agonistic iron death.
    • $34
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    Liproxstatin-1
    T2376950455-15-9
    Liproxstatin-1 is a potent and selective inhibitor of ferroptosis (IC50=22 nM). Liproxstatin-1 protects cells from ferroptosis induced by ferroptosis inducers (e.g., Erastin, RSL3).
    • $48
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    TargetMol | Inhibitor Hot
    Insulin (human)
    Insulin(human), INSULIN
    T822111061-68-0
    Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients.
    • $30
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    TargetMol | Inhibitor Hot
    Oxaliplatin
    L-OHP
    T016461825-94-3
    Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy.
    • $30
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    TargetMol | Inhibitor Hot
    IBMX
    Methylisobutylxanthine, Isobutylmethylxanthine, 3-Isobutyl-1-methylxanthine, 1-Methyl-3-Isobutylxanthine
    T171328822-58-4
    IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM). IBMX enhances the intracellular cAMP level.
    • $33
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    TargetMol | Inhibitor Hot
    (-)-Epigallocatechin Gallate
    Epigallocatechol Gallate, EGCG
    T2988989-51-5
    (-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.
    • $43
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    RMC-7977
    T812632765082-12-8
    RMC-7977 is a highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with anticancer activity for the study of solid tumors with KRAS G12C mutations.
    • $257
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    TargetMol | Inhibitor Hot
    Decitabine
    NSC 127716, Dacogen, 5-Aza-CdR, 5-Aza-2'-deoxycytidine
    T15082353-33-5
    Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
    • $30
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    Rotenone
    Rotocide, Rotenon, Paraderil, Dactinol, Barbasco
    T297083-79-4
    Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces apoptosis.
    • $42
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    Cyclosporin A
    Cyclosporine A, Cyclosporine, Ciclosporin
    T094559865-13-3
    Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM).
    • $36
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    Gemcitabine
    NSC 613327, LY188011
    T025195058-81-4
    Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
    • $34
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    RMC-6236
    RMC6236
    T746982765081-21-6
    RMC-6236 is an orally effective and novel triple complex RAS (ON) MULTI inhibitor, which is a potent non covalent inhibitor of multiple RAS variants in GTP binding state. RMC-6236 has anti-tumor activity and can be used in research related to RAS driven tumors. With rich experience in compound synthesis, we can provide fast customized synthesis services for this product according to your research needs.
    • $58
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    TargetMol | Inhibitor Hot
    Gefitinib
    ZD1839
    T1181184475-35-2
    Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell lung cancers. Gefitinib administration RESULTS in the development of the EGFR C797S resistance mutation.
    • $50
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    TargetMol | Inhibitor Hot
    Ruxolitinib
    INCB018424, (R)-Ruxolitinib
    T1829941678-49-5
    Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis.
    • $53
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    TargetMol | Inhibitor Hot
    LY294002
    SF 1101, NSC 697286, LY 294002
    T2008154447-36-6
    LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
    • $34
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    TargetMol | Inhibitor Hot
    Quercetin
    Sophoretin
    T2174117-39-5
    Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
    • $42
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    TargetMol | Inhibitor Hot
    BI-2493
    T720612937344-16-4In house
    BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
    • $629
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    TargetMol | Inhibitor Hot
    MRTX1133
    T93032621928-55-8In house
    MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.
    • $197
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    TargetMol | Inhibitor Hot
    Erastin
    T1765571203-78-6
    Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations.
    • $41
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    TargetMol | Inhibitor Hot
    ML385
    T4360846557-71-9
    ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhibition of NRF2. ML385 also exhibits anti-tumor activity.
    • $47
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    TargetMol | Inhibitor Hot
    Necrostatin-1
    Necrostatin 1, Nec-1
    T18474311-88-0
    Necrostatin-1 (Nec-1) is a specific RIP1 inhibitor and necrotic apoptosis inhibitor, which inhibits TNF-α-induced necrotic apoptosis and also inhibits IDO.
    • $30
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    5-Fluorouracil
    NSC 19893, Fluorouracil, 5-FU, 5-Fluoracil
    T098451-21-8
    5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.
    • $30
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    Azelaprag
    AMG 986
    T143902049980-18-7In house
    Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.
    • $107
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    TargetMol | Inhibitor Hot
    Bortezomib
    Radiciol, NSC 681239, MG 341, LDP 341, DPBA, Brotezamide
    T2399179324-69-7
    Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective. Bortezomib has antitumor activity and inhibits NF-κB, which can disrupt the cell cycle and induce apoptosis.
    • $48
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    TargetMol | Inhibitor Hot
    Staurosporine
    CGP 41251, Antibiotic AM-2282, AM-2282
    T668062996-74-1
    Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.
    • $56
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    TargetMol | Inhibitor Hot
    RMC-9805
    Zoldonrasib, KRAS G12D inhibitor 18, KRAS G12D IN 18
    T782122922732-54-3
    RMC-9805 is a novel, mutant-selective, covalent and oral KRASG12D (ON) inhibitor. A stable and high affinity triple complex is formed between RMC-9805, KRASG12D, and cyclophilin A, which inhibits signal transduction downstream of KRASG12D (ON) by disrupting its interaction with downstream effectors. RMC-9805 can induce cell apoptosis and promote tumor regression in preclinical KRASG12D tumor models. With rich experience in compound synthesis, we can provide fast customized synthesis services for this product according to your research needs.
    • $132
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    TargetMol | Inhibitor Hot
    Trametinib
    JTP-74057, GSK1120212
    T2125871700-17-3
    Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.
    • $31
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    TargetMol | Inhibitor Hot
    Trastuzumab
    T9912180288-69-1
    Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has been clinically used to treat HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer.
    • $157
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    TargetMol | Inhibitor Hot