T12076L |
ML218
|
1346233-68-8
|
99.45%
|
|
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
|
T28072 |
MLN-3897
|
1010731-97-1
|
98.62%
|
|
MLN-3897 (CCR1 antagonist 10) is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt s...
|
T12419L |
PF-04634817
|
1228111-63-4
|
98%
|
|
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
|
T10756 |
Cenicriviroc Mesylate
|
497223-28-6
|
98%
|
|
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
|
T79095 |
SB-649701
|
935262-95-6
|
98%
|
|
SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].
|
T79096 |
IPG7236
|
2756350-91-9
|
98%
|
|
IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer resear...
|
T82702 |
CMPD167
|
313994-79-5
|
98%
|
|
CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].
|
TN2951 |
3-(hydroxymethyl)cyclopentanone
|
113681-11-1
|
98%
|
|
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
|
T10710 |
CCR1 antagonist 9
|
1220026-26-5
|
98%
|
|
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
|
T11521 |
GW 766994
|
408303-43-5
|
98%
|
|
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
|
T11472L |
Molibresib besylate
|
1895049-20-3
|
98%
|
|
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
|
TQ0182 |
MK-0812
|
624733-88-6
|
98%
|
|
MK-0812 is an effective and specific CCR2 antagonist.
|
T14373 |
AZD2423
|
1229603-37-5
|
98%
|
|
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
|
T17274 |
YM022
|
145084-28-2
|
98%
|
|
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
|
TN3119 |
5-Hydroxy-7,8-dimethoxyflavanone
|
113981-49-0
|
98%
|
|
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
|
T10711 |
CCR2 antagonist 1
|
1683534-96-4
|
98%
|
|
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
|
T14307 |
Aplaviroc
|
461443-59-4
|
98%
|
|
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
|
T10709 |
CCR1 antagonist 7
|
2446154-74-9
|
98%
|
|
CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].
|
T11704 |
JAK-IN-3
|
1400876-94-9
|
98%
|
|
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
|
T14899 |
CCR1 antagonist 8
|
1295298-26-8
|
98%
|
|
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
|