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Immunology/Inflammation CCR

CCR

Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. There have been 20 distinct chemokine receptors discovered in humans. Each has a rhodopsin-like 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling).
Cat No. product name
T24700 R243 R243 is CCR8 signaling and chemotaxis inhibitor.
T4674 SB 297006 SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ...
T14373 AZD2423 AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
T14307 Aplaviroc Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T7624 DAPTA(TFA) DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
TQ0297 Cenicriviroc Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory a...
TQ0283 RS102895 RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
TQ0182 MK-0812 MK-0812 is an effective and specific CCR2 antagonist.
TQ0103 INCB3344 INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM...
T5384 RS 504393 RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
T4584 BMS813160 BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T10425 AZ084 AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
T4300 AZD2098 AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
T3360 ZK 756326 ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 a...
T3327 Arteether Arteether is a new, fast-acting antimalarial drug.
T3435 Vicriviroc maleate Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in cl...
T6016 Maraviroc Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HI...
T2375 BX471 BX471 is a potent, selective non-peptide CCR1 antagonist.
T3188 NSC5844 NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
T3430 PF4136309 INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
T6413 Bindarit Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
T14688 BMS CCR2 22 BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) an...
T14899 CCR1 antagonist 8 CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
TN2951 3-(hydroxymethyl)cyclopentanone 3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
T11521 GW 766994 GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
T17274 YM022 YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
T12419L PF-04634817 PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
T11472L Molibresib besylate Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
T16111 ML604086 ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 bi...
T12076L ML218 ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
T11704 JAK-IN-3 JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T11699 J-113863 J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against...
T10756 Cenicriviroc Mesylate Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
T10714 CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T14900 CCR2-RA-[R] CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
T10156 CCR3 antagonist 1 CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
T10712 CCR2 antagonist 3 CCR2 antagonist 3 is a CCR2 antagonist.
T10711 CCR2 antagonist 1 CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T10710 CCR1 antagonist 9 CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
T10709 CCR1 antagonist 7 CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM).
T10708 CCR1 antagonist 6 CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM).
T12773 RS102895 hydrochloride RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T15253 CCX354 CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
T14909 CCX140 CCX140 (CCX140-B) is an antagonist of CCR2.
T7499 TAK-779 TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
R243
T24700CAS 688352-84-3
R243 is CCR8 signaling and chemotaxis inhibitor.
SB 297006
T4674CAS 58816-69-6
SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ...
AZD2423
T14373CAS 1229603-37-5
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for C...
Aplaviroc
T14307CAS 461443-59-4
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
DAPTA(TFA)
T7624CAS 106362-34-9
DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.
Cenicriviroc
TQ0297CAS 497223-25-3
Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory a...
RS102895
TQ0283CAS 300815-41-2
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
MK-0812
TQ0182CAS 624733-88-6
MK-0812 is an effective and specific CCR2 antagonist.
INCB3344
TQ0103CAS 1262238-11-8
INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM...
RS 504393
T5384CAS 300816-15-3
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
BMS813160
T4584CAS 1286279-29-5
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
AZ084
T10425CAS 929300-19-6
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
AZD2098
T4300CAS 566203-88-1
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
ZK 756326
T3360CAS 874911-96-3
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 a...
Arteether
T3327CAS 75887-54-6
Arteether is a new, fast-acting antimalarial drug.
Vicriviroc maleate
T3435CAS 599179-03-0
Vicriviroc maleate(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in cl...
Maraviroc
T6016CAS 376348-65-1
Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HI...
BX471
T2375CAS 217645-70-0
BX471 is a potent, selective non-peptide CCR1 antagonist.
NSC5844
T3188CAS 140926-75-6
NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
PF4136309
T3430CAS 1341224-83-6
INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
Bindarit
T6413CAS 130641-38-2
Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
BMS CCR2 22
T14688CAS 445479-97-0
BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) an...
CCR1 antagonist 8
T14899CAS 1295298-26-8
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).
3-(hydroxymethyl)cyclopentanone
TN2951CAS 113681-11-1
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the...
GW 766994
T11521CAS 408303-43-5
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
YM022
T17274CAS 145084-28-2
YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histi...
PF-04634817
T12419LCAS 1228111-63-4
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 an...
Molibresib besylate
T11472LCAS 1895049-20-3
Molibresib besylate is an inhibitor of BET bromodomain (IC50: 32.5-42.5 nM).
ML604086
T16111CAS 850330-18-6
ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 bi...
ML218
T12076LCAS 1346233-68-8
ML218 inhibits the burst activity in the subthalamic nucleus (STN) neurons. ML218 is an effective, selective, and orally active inhibitor of T-type Ca2+ channel ...
JAK-IN-3
T11704CAS 1400876-94-9
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
J-113863
T11699CAS 353791-85-2
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against...
Cenicriviroc Mesylate
T10756CAS 497223-28-6
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.
CCR5 antagonist 1
T10714CAS 716354-86-8
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
CCR2-RA-[R]
T14900CAS 512177-83-2
CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
CCR3 antagonist 1
T10156CAS 879399-82-3
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
CCR2 antagonist 3
T10712CAS 1380100-86-6
CCR2 antagonist 3 is a CCR2 antagonist.
CCR2 antagonist 1
T10711CAS 1683534-96-4
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
CCR1 antagonist 9
T10710CAS 1220026-26-5
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay).
CCR1 antagonist 7
T10709CAS T10709
CCR1 antagonist 7 (compound 16r) is a CCR1 antagonist (IC50: 4 nM).
CCR1 antagonist 6
T10708CAS T10708
CCR1 antagonist 6 (compound 16q) is a CCR1 antagonist (IC50: 3 nM).
RS102895 hydrochloride
T12773CAS 1173022-16-6
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
CCX354
T15253CAS 1010073-75-2
CCX354 is a CCR1antagonist. It has anti-inflammatory activity.
CCX140
T14909CAS 1100318-47-5
CCX140 (CCX140-B) is an antagonist of CCR2.
TAK-779
T7499CAS 229005-80-5
TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).