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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T22260 | Aminopurvalanol A | CDK | |
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n... | |||
T3862 | Irigenin | NF-κB , Integrin | |
Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha... | |||
T21981 | Phthalazinone pyrazole | Aurora Kinase | |
Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity. | |||
T13410 | ZLDI-8 | Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related | |
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein. | |||
T0518 | Methacycline hydrochloride | Rondomycin,Methacycline HCl | ribosome , Antibacterial , Antibiotic |
Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period. | |||
T0459 | Sulindac | Arthrocine,MK-231,Clinoril,Sulindac sulfoxide | COX , Autophagy |
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl... | |||
T1725 | Y-27632 dihydrochloride | Y-27632 2HCl | ROCK , Apoptosis |
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. | |||
T37890L | GLP-1(28-36)amide acetate | GLP-1(28-36)amide acetate(1225021-13-5 Free base) | Antioxidant , Glucagon Receptor |
GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities. | |||
T4252 | ML327 | c-Myc , Autophagy | |
ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT). | |||
T21339 | Peramivir | RWJ 270201,BCX1812,BCX 1812,RWJ270201 | |
Peramivir, a neuraminidase inhibitor, acts as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. It is used as an antiviral drug for the... | |||
T15241 | ER-000444793 | Others , Mitochondrial Metabolism | |
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM). | |||
TN1198 | 19-Hydroxybufalin | Others | |
19-Hydroxybufalin is a natural product, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells. | |||
T22402 | Potassium thioacetate | Others | |
Potassium thioacetate has been employed for the synthesis of polymers, heterocycles, nanoparticles, transition-metal ligands, bioactive compounds and macromolecular inclusion complexes. | |||
T9601 | Tepotinib hydrochloride(1 : x) | c-Met/HGFR , P-gp , ABC | |
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations. | |||
T7486 | Imeglimin hydrochloride | EMD 387008 hydrochloride | Reactive Oxygen Species , Mitochondrial Metabolism |
Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. | |||
T20346 | Salicylaldoxime | Others | |
Salicylaldoxime is a chelating agent sometimes used in the analysis of samples containing transition metal ions, with which it often forms brightly colored coordination complexes. | |||
T21481 | Bromophenol Blue | Others | |
Bromophenol Blue, an acid phthalein dye, is utilized both as a tracking dye for electrophoresis and as a pH indicator with a transition range of pH 3 to 4.6. | |||
T8181 | Poricoic acid A | Poricoic acid A(F) | Others |
Poricoic acid A (Poricoic acid A(F)) is a natural product with antitumor activity. It also enhances melatonin inhibition of AKI-to-CKD transition by regulating the Gas6/AxlNFκB/Nrf2 axis. | |||
T12593 | Pyrithione | 1-hydroxyl-1H-pyridine-2-thione | Others |
Pyrithione (1-hydroxyl-1H-pyridine-2-thione) is a transition metal complex, a zinc ionophore, that causes elevated zinc levels in mammalian cells. Pyrithione has potent bactericidal and antifungal activity. | |||
T10404 | ATP synthase inhibitor 1 | ATPase | |
ATP synthase inhibitor 1 is an inhibitor of the c subunit of the F1/FO-ATP synthase complex. It inhibits mitochondrial permeability transition pore (mPTP) opening and does not affect ATP levels. |