tps 2

Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, β-Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, β-Tryptases are released and participate in provoking inflammatory conditions . β-Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders.

TPSAB1, namely tryptase alpha beta-1, is a serine protease with trypsin­like activity. TPSAB1 is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It may play a role in innate immunity. Diseases associated with TPSAB1 include mastocytosis and systemic mastocytosis.

Expression system: P. pastoris (Yeast)
Length: 31-275, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 31-275, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 31-275, Partial
Activity: BLI