tnf-alpha-in-6

TNF-α-IN-6 is an orally efficacious, allosteric inhibitor of TNFα (K_D = 6.8 nM).

Manumycin A is an antibiotic with anticancer activity and is a mammalian thioredoxin reductase-1 (TrxR-1) inhibitor.Manumycin A inhibits the production of IL-1β, IL-6, and IL-8 in TNF alpha-stimulated THP-1 cells and peripheral blood mononuclear cells in a dose-dependent manner, inducing apoptosis.

Glucocorticoid receptor/NF-κB modulator-1 (Compound 20) is a derivative of ocotillol. It prevents degradation of glucocorticoid receptor (GR) mRNA and GR protein and inhibits the activation of the NF-κB signaling pathway. Additionally, it reduces levels of nitric oxide (NO), interleukin (IL-6), and tumor necrosis factor-alpha (TNF-α), and improves sepsis in mice.

Losmapimod hydrochloride (GW856553X) is an orally active, potent, and highly selective p38 alpha/beta MAPK inhibitor (IC50 = 0.8 nM). It greatly reduces the release of pro-inflammatory cytokines, including TNF-alpha and IL-6, by blocking inflammatory signaling cascades, showing remarkable efficacy in COPD and severe cardiovascular inflammation models.

Anti-inflammatory agent 112 (compound 3f) is an inducible nitric oxide synthase (iNOS) inhibitor, cyclooxygenase-2 (COX-2) inhibitor, and anti-inflammatory agent. It suppresses iNOS and COX-2 protein expression, decreases the production of nitric oxide, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), and alleviates lipopolysaccharide (LPS)-induced inflammatory responses. This compound is useful in studying inflammatory diseases.

CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6).

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) is a peptide used as a fluorescence resonance energy transfer (FRET) based substrate for proteolytic activity assays, with cleavage-induced changes in fluorescence intensity indicating enzymatic activity [1].

MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.

GHK-Cu acetate is a tripeptide-copper complex that acts as a regulator of tissue repair during wound healing; it promotes the migration of inflammatory cells and endothelial cells and participates in the remodeling of the extracellular matrix. GHK-Cu acetate can upregulate the expression levels of genes related to collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts, and serves as a key regulator of multiple cellular signaling pathways involved in skin regeneration and tissue repair.

Forsythoside B (Standard) is a reference standard for research and analysis in studies involving Forsythoside B. Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effects with a favorable therapeutic time-window, reduce of cerebral ischemia and reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown; Rescued cardiac function from I/R injury. Forsythoside B has antisepsis effect, is mediated by decreasing local and systemic levels of a wide spectrum of inflammatory mediators.