theophylline

Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac, and central nervous system stimulant activities. It inhibits the 3', 5'-cyclic nucleotide phosphodiesterase that degrades cyclic AMP, thus potentiating the actions of agents that act through adenylyl cyclases and cyclic AMP.

Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Physiologically, this agent relaxes the bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates the cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm.

1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.

Theophylline ephedrine is a pharmacologically active salt used for the treatment of obstructive ventilatory disorders.

Theophylline-platinum(IV) prodrug-1 is a PARP-1 inhibitor. It enhances DNA damage, ROS generation, mitochondrial dysfunction, apoptosis, and S-phase arrest in SKOV3-BRCA1-KD cells while reducing invasion and metastasis. Additionally, it exhibits strong antitumor activity in SKOV3-BRCA1-KD xenograft tumor models. This compound is used for ovarian cancer research.

8-(p-Sulfophenyl)theophylline (8-SPT) (compound 2) is an adenosine A2B receptor antagonist, exhibiting a Ki value of 1330 nM for human recombinant A2B receptors.

Theophylline, 7-ethyl-6-thio- is a bioactive chemical.

Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor that targets PDE3 to relax airway smooth muscle and is used in asthma and chronic obstructive pulmonary disease (COPD) research. It also functions as an adenosine receptor antagonist, histone deacetylase (HDAC) activator, and exhibits anti-inflammatory activity by increasing IL-10 levels and inhibiting NF-κB nuclear import, while inducing apoptosis [1] [2] [3] [4] [5].

Theophylline-D6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline (T1083) is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline (T1083) induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. Formulations containing theophylline have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Theophylline-D6 (Standard) is a reference standard of Theophylline-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Theophylline-d6 is used as an internal standard when quantitatively analyzing Theophylline by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry. Theophylline is a phosphodiesterase inhibitor. It is also an antagonist of adenosine A1 and A2 receptors. Theophylline can cause the relaxation of the bronchial smooth muscle segments that were pre-contracted with acetylcholine in cats.

Theophyllineimpurity 9 is an impurity of Theophylline.

Theophylline EP impurity C, an alkaloid with anti-bronchospasm activity, is employed to assess the purity and quality of compounds. This substance also holds potential clinical value in the management of asthma and chronic obstructive pulmonary disease (COPD).

Lysine theophylline is a soluble theophylline.

Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride is a bioactive chemical.

Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, methiodide is a bioactive chemical.

Theophylline, 7-(2-oxo-4-piperidinobutyl)-6-thio-, hydrochloride is a bioactive chemical.

Theophylline-[13C2,D6] (Standard) is a reference standard of Theophylline-[13C2,D6] intended for quantitative analysis, quality control, and related biochemical research applications.

Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.

Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help offset its stimulant effects

Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.

8-Chlorotheophylline ,with CAS No. 85-18-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 8-Chlorotheophylline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

8-Bromotheophylline (Bromotheophylline) is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, 8-Bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome

8-Chlorotheophylline-D6 is a deuterated compound of 8-Chlorotheophylline (PDK0377). 8-Chlorotheophylline (PDK0377) has a CAS number of 85-18-7.

8-Chlorotheophylline-D6 (Standard) is a reference standard of 8-Chlorotheophylline-D6 intended for quantitative analysis, quality control, and related biochemical research applications. 8-Chlorotheophylline-d6 is a deuterated compound of 8-Chlorotheophylline. 8-Chlorotheophylline has a CAS number of 85-18-7.