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Banoxantrone (AQ4N), a hypoxia-selective cytotoxin prototype, undergoes reduction to AQ4, effectively inhibiting topoisomerase II. It selectively targets and eradicates hypoxic cells through an iNOS-dependent mechanism. This compound demonstrates significant cytotoxicity with its hypoxia-selective action being augmented by radiation.

NSC 42196 (Calcium glucoheptonate) is the calcium salt of (2xi)-D-gluco-heptonic acid. NSC 42196 is used as a calcium supplement for treatment of hypocalcemia.

NSC 405020 is a noncatalytic inhibitor of MT1-MMP.

NSC-409012 (5-(4-iodobenzylidene)rhodanine) is an active compound that has been found to have a variety of biochemical and physiological effects, including regulation of gene expression, cell proliferation and apoptosis. It also possesses anti-inflammatory, anti-tumor, antioxidant and antifungal activities.

NSC 404988 is a benzamide-based bioactive compound used in the synthesis of compounds and the preparation of drugs, and has also been used in the study of drug metabolism and the analysis of metabolites in biological systems.

NSC 4810 is an amide bioactive compound that has been used as a substrate for cytochrome P450 enzymes in vivo and as a substrate for acetylcholinesterase in vitro.

SC 44914, a quinoxaline compound, exhibits antimicrobial properties. It is active against Campylobacter jejuni, Escherichia coli, and Clostridium difficile.

SC 4453 is a digoxin analog and a cardiac glycoside derivative.

SC 45694 is a leukotriene B4 (LTB4) analog.

SC 46944 is a highly potent human renin inhibitor.

SC 42619 is a tripeptide analogue that inhibits aggregation of, and secretion from, human platelets.

SC 42867 is a PGE2 antagonist.

NSC 48160 is a small molecule compound with anti-pancreatic cancer activity that inhibits the growth of pancreatic cancer cells, induces apoptosis of pancreatic cancer cells through the mitochondrial pathway and inhibits metastasis of two types of pancreatic cancer cells in vitro, and can freeze the intermediate of Ras-GTP hydrolysis in the open non-signaling conformation with high affinity and high specificity in silico.

Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.

MSA-2 dimer, a selective and orally active non-nucleotide STING agonist with a dissociation constant (Kd) of 145 μM, demonstrates prolonged antitumor and immunogenic activity. It non-covalently binds to STING as a dimer, showing greater permeability compared to cyclic dinucleotide[1].

Metronidazole hydrochloride (SC 326421), an orally active nitroimidazole antibiotic, is effective for researching anaerobic infections. This compound is capable of crossing the blood-brain barrier and may cause inflammation and skeletal muscle contraction with long-term use [1] [2] [3] [4].