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SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.

Banoxantrone (AQ4N), a hypoxia-selective cytotoxin prototype, undergoes reduction to AQ4, effectively inhibiting topoisomerase II. It selectively targets and eradicates hypoxic cells through an iNOS-dependent mechanism. This compound demonstrates significant cytotoxicity with its hypoxia-selective action being augmented by radiation.

4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity. 4SC-203 exhibits unique selectivity for Flt3, Flt3 mutants, Axl, Alk, Fak, VEGF-R2, and Trk receptors in the low nM range.

Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor targeting HDAC1/2/3 with IC50 values of 1.20/1.12/0.57 μM, respectively, and also inhibits Lysine-specific demethylase 1 (LSD1).

Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.

4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. 4SC-207 may be a potential anti-cancer agent.

4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.

4A3-SC7 is a polymer of 4A3 amine and functions as an ionizable lipid. It can be utilized in the formation of lipid nanoparticles (LNP) to develop a Selective Organ Targeting (SORT) LNP platform.

NSC 42196 (Calcium glucoheptonate) is the calcium salt of (2xi)-D-gluco-heptonic acid. NSC 42196 is used as a calcium supplement for treatment of hypocalcemia.

NSC-409012 (5-(4-iodobenzylidene)rhodanine) is an active compound that has been found to have a variety of biochemical and physiological effects, including regulation of gene expression, cell proliferation and apoptosis. It also possesses anti-inflammatory, anti-tumor, antioxidant and antifungal activities.

NSC 404988 is a benzamide-based bioactive compound used in the synthesis of compounds and the preparation of drugs, and has also been used in the study of drug metabolism and the analysis of metabolites in biological systems.

NSC 4810 is an amide bioactive compound that has been used as a substrate for cytochrome P450 enzymes in vivo and as a substrate for acetylcholinesterase in vitro.

NSC 405020 is a noncatalytic inhibitor of MT1-MMP.

SC 44914, a quinoxaline compound, exhibits antimicrobial properties. It is active against Campylobacter jejuni, Escherichia coli, and Clostridium difficile.

SC 4453 is a digoxin analog and a cardiac glycoside derivative.

SC 45694 is a leukotriene B4 (LTB4) analog.

SC 46944 is a highly potent human renin inhibitor.

SC 42619 is a tripeptide analogue that inhibits aggregation of, and secretion from, human platelets.

SC 42867 is a PGE2 antagonist.

NSC 48160 is a small molecule compound with anti-pancreatic cancer activity that inhibits the growth of pancreatic cancer cells, induces apoptosis of pancreatic cancer cells through the mitochondrial pathway and inhibits metastasis of two types of pancreatic cancer cells in vitro, and can freeze the intermediate of Ras-GTP hydrolysis in the open non-signaling conformation with high affinity and high specificity in silico.

Denifanstat (FASN-IN-2) is a fatty acid synthase (FASN) inhibitor (IC50=0.052 μM, EC50=0.072 μM) with selective and oral activity. Denifanstat has been used in studies of steatohepatitis.

Bidisomide (SC40230) is an agent of class I antiarrhythmic.

Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin-dependent kinase activity in p53-mediated cell cycle arrest.

Cortisone Acetate is a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory and immunomodulating properties. Cortisone acetate (NSC-49420) diffuses through the cell membrane and binds to nuclear glucocorticoid receptors. The receptor-ligand complex binds to promotor regions of certain genes and initiates RNA transcription. This results in an induction of synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators.