rna modification

3-Methyluridine is a modified nucleoside of cellular RNA.

N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/differentiation and improves the efficiency

N6-Methyladenosine is a methylated adenine residue, glycoside is an endogenous uridine product of transfer RNA degradation. It is the most prevalent internal modification of messenger RNA present in all higher eukaryotes and can modify viral RNA with antiviral activity.

5-Methyl-5,6-dihydrouridine, a minor constituent in the chromosomal RNA of the rat ascites tumor, can be utilized for nucleic acid modification.

METTL3-IN-9 (compound C3) serves as an inhibitor of the RNA methyltransferase known as methyltransferase-like METTL3. This enzyme is responsible for catalyzing the N6-methyladenosine (m6A) modification of mRNA within eukaryotic cells.

1-Methyladenosine-D3 is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine (T7571) upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.

1-Methyladenosine-D is the deuterated form of 1-Methyladenosine. This compound is an RNA modification and serves as a tumor marker, with elevated levels in the body linked to cancer development. Methylated 1-Methyladenosine (T7571) can promote liver tumor development by upregulating PPARδ expression, regulating cholesterol metabolism, and activating the Hedgehog signaling pathway.

5S rRNA modificator (FAI), used in 5S rRNA RNA modification, is a suitable electrophile for 2'-hydroxyl acylation on structured RNA molecules.

N1-Methylpseudouridine-5'-triphosphate is a modified nucleotide derivative commonly used to explore RNA modification, synthesis, and function, and can replace UTP in synthesis thereby improving RNA stability and reducing immunogenicity.

Cemdisiran, an investigational N-acetylgalactosamine-conjugated RNAi (RNA interference) agent with terminal sugar modification, is a small interfering RNA (siRNA) designed to specifically target and suppress the C5 mRNA, thereby reducing the liver's production of the complement component C5 [1].

Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP. This modification enhances RNA stability and augments mRNA translation efficiency in eukaryotic cells, evidencing the enzyme's high tailing efficiency [1] [2].

Fmoc-L-Asn(EDA-N3)-OH is a chemical compound equipped with an azide group used in click chemistry. Reports in the literature have demonstrated its application in the modification of α-amanitin, the deadliest member of the amatoxin peptide family produced by the death cap mushroom. α-Amanitin is a highly lethal natural compound (LD50=50-100 µg/kg), an orally ingested rigid bicyclic octapeptide, acting as a highly selective conformational inhibitor of RNA polymerase II.

1-Methyladenosine-D3 hydrochloride is the deuterium-labeled hydrochloride salt form of 1-Methyladenosine. This compound is known as an RNA modification and serves as a tumor marker, as elevated levels in the body are associated with cancer development. Post-methylation, 1-Methyladenosine can drive liver tumor formation by upregulating PPARδ expression, regulating cholesterol metabolism, and activating the Hedgehog signaling pathway.

N4-Acetyl-2'-O-methylcytidine (ac4Cm) is a doubly modified RNA nucleoside bearing both N4-acetylation and 2'-O-methylation that is predominantly identified in thermophilic archaea. N4-Acetyl-2'-O-methylcytidine contributes to molecular adaptation under extreme environmental conditions by enhancing RNA structural stability, resistance to thermal degradation, and translational fidelity through synergistic chemical modification.

N4-Methyl-2'-O-methyl-cytidine is a modified cytidine analog that has been used as an antibiotic and research reagent, inhibiting bacterial protein synthesis through ribosomal binding, N4-Methyl-2'-O-methyl-cytidine is also utilized in the study of enhancement RNA stability in thermophilic organisms, supporting investigations into translational control, RNA modification, and nucleoside-based antimicrobial strategies.

Nucleoside; Used for RNA synthesis and special nucleoside modification

Nucleoside; Used for special nucleoside or RNA modification

2'-O-Methyl nucleoside; Used for RNA synthesis and nucleoside modification

Microcin J25 (MccJ25) is a cyclic peptide antibiotic and ribosomal synthesis post-translational modification peptide (RiPP) produced by Escherichia coli. It inhibits DNA-dependent RNA polymerase (RNAP) in Gram-negative bacteria and exhibits antibacterial activity.

DEAE-dextran, MW 500000 hydrochloride is a cationic polysaccharide derivative obtained by diethylaminoethyl (DEAE) modification of dextran derived from Leuconostoc mesenteroides. DEAE-dextran, MW 500000 hydrochloride facilitates cellular uptake of nucleic acids by forming complexes with them and is commonly used to enhance the delivery of RNA or DNA into cells. DEAE-dextran, MW 500000 hydrochloride is widely applied as a tool in gene delivery and transfection studies and can also be used for liposome surface modification.