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Search Results for " prostacyclin "

20

Compounds

Cat No. Product Name Synonyms Targets
T15238 Epoprostenol sodium Prostaglandin I2 sodium salt,Prostacyclin sodium salt,Flolan Others
Epoprostenol sodium is a potent inhibitor of platelet aggregation used in pulmonary hypertension and transplantation.
T26745 BAY 73-1449 BAY-73-1449,BAY73-1449 Others
BAY-73-1449 is an antagonist of prostacyclin receptor.
T36236 5-cis Carbaprostacyclin
5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 μM compared to 0.3 μM for carbaprostacyclin. 5-cis Carbapros...
T36774 13,14-dehydro-15-cyclohexyl Carbaprostacyclin
13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. It inhibits the ADP-induced aggregation of human platelets with an ED50 of about 40 nM in PRP and 77 nM in washed platelets, which is c...
T69360 RO3244794 Prostaglandin Receptor
RO3244794 is a selective prostacyclin (IP) receptor antagonist that can be used to study liver injury.
T21443 Prednicarbate Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D Others
Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibit...
TMA0536 2-Acetylbenzoic acid Prostaglandin Receptor
2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyc...
T3216 Selexipag NS-304,ACT-293987,Uptravi Others , Prostaglandin Receptor
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH).
T3S2007 MRE-269 MRE 269,ACT-333679,MRE269 Prostaglandin Receptor
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary arterial hypertension. MRE-269(ACT-333679) is an active metabo...
T4635 Ralinepag APD811 Others , Prostaglandin Receptor
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
TP1277 Bradykinin Endogenous Metabolite , Bradykinin Receptor
Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol...
T4436 RO1138452 CAY10441 Others , Prostaglandin Receptor
RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cycli...
T34796 TEI-9063 TEI9063
TEI-9063 is a stable and highly specific prostacyclin analogue of prostacyclin receptor in mast cell tumor p-815 cells.
T71025 KP 10614
KP 10614 is a new prostacyclin analog that inhibits platelet-polymorphonuclear leukocyte interaction.
T68751 Hoe 892
Hoe 892 is a stable thia-thimo-analogue of prostacyclin and acts as a platelet aggregation inhibitor.
T10673 Carbacyclin Carbaprostacyclin,Carba-PGI2 Others
Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.
T30426 Beraprost ML 1229,MDL 201229,ML-1229,MDL-201229
Beraprost is a stable prostacyclin analog.
T38171 Ro 1138452 hydrochloride
Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailabl...
T33579 Nafazatrom Nafazatromum
Nafazatrom is a pyrazolinone derivative and lipoxygenase inhibitor that increases endogenous prostacyclin (PGI2) and has experimental anticancer activity. Nafazatrom is also an antithrombotic drug that increases prostacy...
T28254 OP-2507
OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension.
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