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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15238 | Epoprostenol sodium | Prostaglandin I2 sodium salt,Prostacyclin sodium salt,Flolan | Others |
Epoprostenol sodium is a potent inhibitor of platelet aggregation used in pulmonary hypertension and transplantation. | |||
T26745 | BAY 73-1449 | BAY-73-1449,BAY73-1449 | Others |
BAY-73-1449 is an antagonist of prostacyclin receptor. | |||
T36236 | 5-cis Carbaprostacyclin | ||
5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 μM compared to 0.3 μM for carbaprostacyclin. 5-cis Carbapros... | |||
T36774 | 13,14-dehydro-15-cyclohexyl Carbaprostacyclin | ||
13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. It inhibits the ADP-induced aggregation of human platelets with an ED50 of about 40 nM in PRP and 77 nM in washed platelets, which is c... | |||
T69360 | RO3244794 | Prostaglandin Receptor | |
RO3244794 is a selective prostacyclin (IP) receptor antagonist that can be used to study liver injury. | |||
T21443 | Prednicarbate | Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D | Others |
Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibit... | |||
TMA0536 | 2-Acetylbenzoic acid | Prostaglandin Receptor | |
2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyc... | |||
T3216 | Selexipag | NS-304,ACT-293987,Uptravi | Others , Prostaglandin Receptor |
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH). | |||
T3S2007 | MRE-269 | MRE 269,ACT-333679,MRE269 | Prostaglandin Receptor |
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary arterial hypertension. MRE-269(ACT-333679) is an active metabo... | |||
T4635 | Ralinepag | APD811 | Others , Prostaglandin Receptor |
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively. | |||
TP1277 | Bradykinin | Endogenous Metabolite , Bradykinin Receptor | |
Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol... | |||
T4436 | RO1138452 | CAY10441 | Others , Prostaglandin Receptor |
RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cycli... | |||
T34796 | TEI-9063 | TEI9063 | |
TEI-9063 is a stable and highly specific prostacyclin analogue of prostacyclin receptor in mast cell tumor p-815 cells. | |||
T71025 | KP 10614 | ||
KP 10614 is a new prostacyclin analog that inhibits platelet-polymorphonuclear leukocyte interaction. | |||
T68751 | Hoe 892 | ||
Hoe 892 is a stable thia-thimo-analogue of prostacyclin and acts as a platelet aggregation inhibitor. | |||
T10673 | Carbacyclin | Carbaprostacyclin,Carba-PGI2 | Others |
Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation. | |||
T30426 | Beraprost | ML 1229,MDL 201229,ML-1229,MDL-201229 | |
Beraprost is a stable prostacyclin analog. | |||
T38171 | Ro 1138452 hydrochloride | ||
Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailabl... | |||
T33579 | Nafazatrom | Nafazatromum | |
Nafazatrom is a pyrazolinone derivative and lipoxygenase inhibitor that increases endogenous prostacyclin (PGI2) and has experimental anticancer activity. Nafazatrom is also an antithrombotic drug that increases prostacy... | |||
T28254 | OP-2507 | ||
OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension. |