phenytoin

Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. It potentially acts by promoting sodium efflux from neurons in the motor cortex, reducing post-tetanic potentiation at synapses. This prevents cortical seizure foci from spreading to adjacent areas and stabilizes the threshold against hyperexcitability. Additionally, it appears to reduce muscle spindle sensitivity to stretch, causing muscle relaxation.

Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .

Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal slices. It protects against seizures induced by maximal electroshock (MES) in mice. Formulations containing phenytoin have been used in the treatment of tonic-clonic seizures and status epilepticus.

Fosphenytoin is a phosphate prodrug that can be used as an alternative to intravenous phenytoin for the acute intervention of seizures.Fosphenytoin is hydrolyzed to anticonvulsant phenytoin when administered parenterally.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.

4-Hydroxymephenytoin ((+ -)-4'-Hydroxymephenytoin) is the metabolism of an antiepileptic drug mephenytoin. Mephenytoin is used as a CYP2C19 substrate.

(R)-Mephenytoin ((–)-Mephenytoin) is the the R-enantiomer of Mephenytoin which is an anticonvulsant agent.

Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker

Fosphenytoin Sodium-d10 is a deuterated compound of Fosphenytoin Sodium. Fosphenytoin Sodium has a CAS number of 92134-98-0. Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker

Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.

(S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsant that serves as a substrate of the cytochrome P450 (CYP) isoform CYP2C19 and is used to analyze cytochrome P450 metabolism.

3-Hydroxymephenytoin is a bioactive chemical.

Denzimol hydrochloride is a new anticonvulsant drug that inhibits electrically and chemically induced tonic seizures but does not stop clonic seizures. It behaves similarly to phenytoin and carbamazepine, but differently from barbiturates and benzodiazepines.

Ethotoin (Peganone), an orally active anticonvulsant agent utilized in epilepsy research, is a hydantoin derivative analogous to phenytoin [1].