pbd-1

pBD-1 is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites with the contribution of mucosal and systemic host defenses in pigs.

pBD-1 TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs.

pBD-1 TFA, an endogenous antimicrobial peptide (AMP) from porcine tissues, is constitutively expressed, particularly at pig mucosal epithelial sites. It exhibits antimicrobial activities, contributing to both mucosal and systemic host defenses in pigs [1].

PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)

Nonanoic acid (Nonoic acid) is a fatty acid which occurs naturally as esters are the oil of pelargonium. Synthetic esters, such as methyl nonanoate, are used as flavorings. Pelargonic acid is an organic compound composed of a nine-carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. It is nearly insoluble in water, but well soluble in chloroform and ether.

MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].

DBCO-PEG4-VA-PBD is a cleavable 4-unit PEG ADC linker utilized in antibody-drug conjugate (ADC) synthesis [1].

MP-PEG8-VA-PABC-PBD Dimer is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication[1].

Plk1 PBD-IN-143 is a novel Inhibitor of the Polo-Box Domain of Polo-like Kinase 1 (Plk1 PBD).

Antibiotic DC 81, a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor antibiotic produced by Streptomyces species, acts as a potent inhibitor of nucleic acid synthesis. It specifically recognizes and binds to certain DNA sequences, forming a labile covalent adduct [1] [2].

Anthramycin, a potent antibiotic and member of the pyrolobenzodiazepine (PBD) family, exhibits significant antitumor activity. Additionally, it functions as a potent antagonist of cholecystokinin in the central nervous system of mice [1] [2] [3].

Mipasetamab uzoptirine (ADCT-601) is an antibody-drug conjugate (ADC) targeting AXL, combining a humanized anti-AXL antibody with a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199, used in cancer research [1].

PBD dimer-2 (compound 2c), a C8-linked pyrrolobenzodiazepine dimer, has the capability to span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. It serves as a potential payload for antibody–agent conjugates (ADCs) and is under research for cancer treatments [1] [2].

PLK1-IN-10 (Compound 4Bb), an orally active inhibitor of the PLK1 PBD (polo-box domain), inhibits the interaction between PLK1 and the cell division regulator protein 1 (PRC1) and reduces the protein expression of the CDK1-Cyclin B1 complex. Additionally, PLK1-IN-10 interacts with glutathione (GSH), enhancing cellular oxidative stress and promoting cell death [1].

PBD-monoamide, a modified pyrrolobenzodiazepine (PBD) dimer, functions as an ADC cytotoxin. It is utilized in synthesizing DHES0815A (an HER2 ADC) and possesses DNA-binding activity that reduces cell viability [1].

Serclutamab talirine (ABBV-321), an EGFR-targeted antibody-drug conjugate (ADC), comprises the AM-1-ABT-806 antibody, which targets activated EGFR, and a pyrrolobenzodiazepine (PBD) dimer. This compound displays potent antitumor activity [1].

Olintatug (ADCT-901) is a highly specialized antibody-drug conjugate (ADC) targeting Kidney-Associated Antigen 1 (KAAG1). It comprises a humanized monoclonal antibody conjugated to a potent pyrrolobenzodiazepine (PBD) dimer cytotoxin via a cathepsin-cleavable linker. Olintatug specifically binds to KAAG1 on tumor cell surfaces, internalizes, and releases the PBD dimer, which induces lethal DNA interstrand cross-links, blocking cell division. It is investigated for KAAG1-expressing solid tumors, including ovarian and triple-negative breast cancers.

Nonanoic acid-D17 is the deuterated form of Nonanoic acid. Nonanoic acid (T3947) is a naturally occurring saturated fatty acid composed of nine carbon atoms. It is known to significantly reduce bacterial translocation, enhance antibacterial activity, and notably increase the secretion of porcine β-defensin 1 (pBD-1) and pBD-2.

Nonanoic acid-D2 is the deuterated form of Nonanoic acid, which is a naturally occurring saturated fatty acid with a nine-carbon structure. Nonanoic acid (T3947) significantly reduces bacterial translocation, enhances antimicrobial activity, and notably increases the secretion of porcine β-defensin 1 (pBD-1) and pBD-2.

Nonanoic acid-D4 is the deuterated form of Nonanoic acid. Nonanoic acid (T3947) is a naturally occurring saturated fatty acid with nine carbon atoms. It notably reduces bacterial translocation, enhances antimicrobial activity, and significantly increases the secretion of porcine β-defensin 1 (pBD-1) and pBD-2.

Nonanoic acid-D3 is a deuterated form of Nonanoic acid. Nonanoic acid is a naturally occurring saturated fatty acid with nine carbon atoms. It significantly reduces bacterial translocation, enhances antibacterial activity, and markedly increases the secretion of pig β-defensin 1 (pBD-1) and pBD-2.

Nonanoic acid (Standard) is the standard substance of Nonanoic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nonanoic acid (Nonoic acid) is a fatty acid which occurs naturally as esters are the oil of pelargonium. Synthetic esters, such as methyl nonanoate, are used as flavorings. Pelargonic acid is an organic compound composed of a nine-carbon chain terminating in a carboxylic acid. It is an oily liquid with an unpleasant, rancid odor. It is nearly insoluble in water, but well soluble in chloroform and ether.

Nonanoic Acid-D17 (Standard) is a reference standard of Nonanoic Acid-D17 intended for quantitative analysis, quality control, and related biochemical research applications. Nonanoic acid-d17 is the deuterated form of Nonanoic acid. Nonanoic acid is a naturally occurring saturated fatty acid composed of nine carbon atoms. It is known to significantly reduce bacterial translocation, enhance antibacterial activity, and notably increase the secretion of porcine β-defensin 1 (pBD-1) and pBD-2.

Nonanoic Acid-D3 (Standard) is a reference standard of Nonanoic Acid-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Nonanoic acid-d3 is a deuterated form of Nonanoic acid. Nonanoic acid is a naturally occurring saturated fatty acid with nine carbon atoms. It significantly reduces bacterial translocation, enhances antibacterial activity, and markedly increases the secretion of pig β-defensin 1 (pBD-1) and pBD-2.