nrp 1

Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors.

Expression system: HEK293 Cells
Length: 1-644, Full Length
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-344, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-644, Full Length
Activity: BLI、ELISA

Expression system: HEK293 Cells
Length: 1-856, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-644, Full Length
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-856, Partial
Activity: ELISA

Neuropilin-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.33 kDa and the accession number is NP_001019799.2.

Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.31 kDa and the accession number is NP_001019799.2.