nitroimidazole

Ronidazole (Ronidazol) is an antiprotozoal and antimicrobial agent used mainly in veterinary practice.

Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected to be carcinogenic and mutagenic to humans. Hydroxy dimetridazole is a metabolite of dimetridazole that may be useful for identifying this nitroimidazole in various agricultural samples through liquid chromatography-tandem mass spectrometry and other methods.

Fexinidazole (HOE 239) is an antiparasitic agent with activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone.

5-Nitroimidazole ,with CAS No. 3034-38-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Nitroimidazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Methyl-4-nitroimidazole is a useful organic compound for research related to life sciences. The catalog number is T65596 and the CAS number is 3034-41-1.

5-Chloro-1-methyl-4-nitroimidazole, catalog number T67500 and CAS number 4897-25-0, is a valuable organic compound for life sciences research.

1-Methyl-5-nitroimidazole ,with CAS No. 3034-42-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Methyl-5-nitroimidazole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Methyl-4-nitroimidazole (2-MNI) is a heterocyclic compound with antimicrobial, anti-inflammatory, and antitumor activities.2-MNI has been used in a variety of fields including biochemistry, pharmacology, and biotechnology.

4-Nitroimidazole (Standard) is the standard substance of 4-Nitroimidazole, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments.

5-Chloro-1-methyl-4-nitroimidazole (Standard) is the standard substance of 5-Chloro-1-methyl-4-nitroimidazole, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 5-Chloro-1-methyl-4-nitroimidazole is a useful organic compound for research related to life sciences. The catalog number is T67500 and the CAS number is 4897-25-0.

2-Methyl-5-nitroimidazole (Standard) is a reference standard of 2-Methyl-5-nitroimidazole intended for quantitative analysis, quality control, and related biochemical research applications.

Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) is a drug that combats protozoan infections. It is a nitroimidazole class drug. It has been banned by the Canadian government as a livestock feed additive.

EF-5 (2-Nitroimidazole) is a agent of hypoxia labeling. It is used to identify hypoxia in cells.

Azomycin (Ro 05-9129) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica.

SR4554 is a fluorinated 2-nitroimidazole non-invasive tumor hypoxia probe for the detection of tumor hypoxia as detected by 19F magnetic resonance spectroscopy (MRS).

Moxnidazole, a 5-nitroimidazole, is mutagenic in microbial assays and in Drosophila, inducing genetic alterations in mouse somatic cells.

Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa.

Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group, in turn, is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.

Ornidazole (Tiberal) is a nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action.

Dextrorotation nimorazole phosphate ester is an anti-anaerobic and anti-parasitic agent. D-morpholine ornidazole organic phosphate, a highly efficient and well-tolerated fourth-generation nitroimidazole derivative, has been newly developed for antibacterial purposes.

Lu-AAZTA-NI-PSMA-093, a bivalent radiopharmaceutical agent designed for prostate cancer treatment, improves tumor targeting and retention. This is achieved by integrating a hypoxia-sensitive nitroimidazole (NI) group with a prostate-specific membrane antigen (PSMA) targeting moiety.

Sulnidazole, a nitroimidazole derivative, functions as an antiprotozoal compound effective against Trichomonas vaginalis.

Nimorazole (Nimorazol) is a nitroimidazole anti-infective.