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Results for "

neurotoxicity

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    94
    TargetMol | Inhibitors_Agonists
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    1
    TargetMol | Compound_Libraries
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Ferrostatin-1
Ferrostatin-1 (Fer-1), Ferrostatin 1
T6500347174-05-4
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and antifungal activities.
  • $59
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Idebenone
CV-2619
T041258186-27-9
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).
  • $40
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Benzamide
Phenylcarboxyamide, Benzoylamide, Amid kyseliny benzoove
T678055-21-0
Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
  • $30
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Tolmetin
Tolectin
T255026171-23-3
Tolmetin (Tolectin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds.
  • $33
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Talatisamine
T3S187320501-56-8
1. Talatisamine (12 μM) and TEA (5mM) inhibits the enhanced I(K) caused by Aβ4 oligomers, attenuates cytotoxicity of Aβ oligomers by restoring cell viability and suppressing K(+) loss related apoptotic response. 2. Talatisamine can therefore be considered
  • $33
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Hibifolin
TN173655366-56-8
Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.
  • $32
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Oxidopamine hydrobromide
6-OHDA hydrobromide, 6-Hydroxydopamine hydrobromide
T12352L636-00-0
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
  • $30
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Oxidopamine hydrochloride
6-OHDA hydrochloride, 6-Hydroxydopamine hydrochloride
T1235228094-15-7
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).
  • $39
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DB04760
MMP-13 Inhibitor
T15055544678-85-5In house
DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity.
  • $80
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Erbulozole
R-55104, R55104, R 55104
T25384124784-31-2In house
Erbulozole (R 55104) is a potent synthetic microtubule inhibitor with anti-invasive, anti-tumor, and radiosensitizing activities that induces Wernicke's encephalopathy-like neurotoxicity.
  • $628
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Copper histidine
T6798177280-83-2In house
Copper histidine inhibited Ctr1-mediated cellular uptake of oxaliplatin in vitro without altering oxaliplatin accumulation of platinum or neurotoxicity in DRG tissues in vivo. Copper histidine is administered orally for the treatment of Menkes disease.
  • $76
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Orphenadrine
Orphenadrine (free base)
T6859983-98-7In house
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagonist of central and peripheral muscarinic receptors. Attenuation is blocked by mutations in pore residues Y652 or F656. Orphenadrine has antispasmodic, analgesic, and anticholinergic activity and protects against glutamatergic neurotoxicity in vitro and in vivo.Orphenadrine has inhibitory effects on sodium channels and can be used in the treatment of Parkinson's disease.
  • $52
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S1R agonist 2
T72059150085-21-5In house
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
  • $34
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Fenobucarb
T360923766-81-2
Fenobucarb is a broad-spectrum carbamate insecticide and AChE inhibitor primarily used to control various flukes damaging crops. It exhibits neurotoxicity to zebrafish foetal development and induces muscle spasms and paralysis in insects, fish, and mammals.
  • $30
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1-Aminocyclopropane-1-carboxylic acid
ACC, 1-Aminocyclopropanecarboxylic acid, 1-Amino-1-carboxycyclopropane
T475222059-21-8
1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.
  • $30
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D-Arabitol
D-Lyxitol
T5268488-82-4
D-Arabitol is a polyol that can lead to neurotoxicity when accumulated in the body.
  • $29
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Tetrahydropapaverine hydrochloride
Tetrahydropapaverine HCl, Tetrahydroalkali hydrochloride, Norlaudanosine HCl
T60046429-04-5
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
  • $34
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TargetMol | Inhibitor Sale
AM281
T2264202463-68-1
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
  • $77
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Cefepime
BMY-28142
T0868L88040-23-7
Cefepime (BMY-28142) is a cephalosporin antibiotic with antimicrobial activity, induces neurotoxicity, inhibits both Gram-positive and Gram-negative, and can be used in the study of anaerobic bacteria.
  • $32
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Capsaicin
Zostrix, Qutenza, 8-Methyl-N-vanillyl-trans-6-nonenamide, (E)-Capsaicin
T1062404-86-4
Capsaicin is an active natural component found in chili peppers and acts as a TRPV1 agonist (EC50 = 0.29 μM). It possesses multiple activities, including pain relief, antitumor, anti-inflammatory, antioxidant, and neuroprotective effects, as well as some neurotoxicity. Capsaicin can be used to establish itch models.
  • $50
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PQM130
T125322089415-51-8
PQM130 is a neuroprotective compound ,and is a potential anti-AD drug.
  • $38
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AG-825
Tyrphostin AG-825
T14138149092-50-2
AG-825(Tyrphostin C15) is a selective and competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation with an IC50 value of 0.35 μM.AG-825 (Tyrphostin C15) inhibits HER2 and shows anticancer activity in a mouse xenograft model of breast cancer.AG-825 ( Tyrphostin C15) is a potentially active molecule for overcoming manganese-induced neurotoxicity or the development of Alzheimer's disease, and promotes apoptosis in human neutrophils, which could be used in the study of breast cancer.
  • $30
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CI-943
(±)-CI-943
T1496389239-35-0
CI-943 is a novel potential antipsychotic drug that does not bind to dopamine (DA) receptors and has some developmental neurotoxicity.
  • $1,670
6-8 weeks
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Indibulin
ZIO 301, D 24851
T15576204205-90-3
Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.
  • $34
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