maleimide

Azido-PEG3-maleimide is a PEG-based PROTAC linker used primarily for the synthesis of PROTACs[1] and also functions as a cleavable 3-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].

Sulfo DBCO-PEG4-Maleimide is a PEGylated derivative with a maleimide group, commonly used as a linker for synthesizing PROteolysis TAgeting Chimeras (PROTACs)[1].

DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker used in the synthesis of PROTACs [1].

DBCO-NHCO-PEG2-maleimide is a polyethylene glycol (PEG) derived PROTAC linker utilized in PROTAC synthesis [1].

DBCO-NHCO-PEG6-maleimide is a polyethylene glycol (PEG)-based linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DSPE-PEG-Maleimide (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Methyltetrazine-PEG6-maleimide is a PEG-derived linker compound used for synthesizing PROTACs [1].

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in synthesizing antibody-drug conjugates (ADCs) and is essential in producing the ADC compound Gemcitabine-O-Si(di-iso)-O-Mc [1].

TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

TCO-PEG5-maleimide, a PEG-based linker for PROTACs, joins two essential ligands essential for PROTAC molecule formation and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG9-maleimide is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Maleimide-C10-NHS ester is an alkyl/ether-based linker utilized in PROTAC synthesis.

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-like PROTAC linker that can be used to synthesize PROTAC molecules.

Alkyne-PEG4-maleimide is a PEG-based bifunctional linker designed for the construction of PROTAC molecules, enabling covalent conjugation between ligand moieties via its terminal alkyne and maleimide groups, and facilitating selective protein degradation through ubiquitin–proteasome system recruitment.

DBCO-Maleimide (DBCO-MAL) is a non-cleavable ADC linker for the synthesis of ADC compounds.

DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions.

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that synthesises PROTAC molecules. Methyltetrazine-PEG4-maleimide contains a Tetrazine moiety and can undergo an iEDDA click with molecules containing a TCO moiety.

Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

Mal-amido-PEG9-acid is a PEG-based linker for PROTACs, crucial for joining two essential ligands and facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-amido-PEG12-NHS ester (Maleimide-PEG12-NHS ester) is a PEG-based PROTAC linker and can be used to synthesize PROTAC molecules.

Mal-amido-PEG16-acid is a PEG-based linker used in PROTAC molecules, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

TCO4-PEG2-Maleimide, a PEG-based PROTAC linker, features TCO and Maleimide groups that enable specific "click" reactions with tetrazine groups or react with thiol groups through "thiol-ene" reactions.

TCO4-PEG2-Maleimide is a PROTAC linker classified under the PEG category. This compound features TCO and Maleimide groups, enabling it to participate in specific "click" reactions with tetrazine groups or "thiol-maleimide" reactions with thiol groups.

TCO4-PEG7-Maleimide is a PROTAC linker from the PEG class. This compound includes TCO and Maleimide groups, which can specifically engage in "click" reactions with tetrazine groups or in "thiol-maleimide" reactions with thiol groups.