maleimide

Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.

Azido-PEG3-maleimide is a PEG-based PROTAC linker used primarily for the synthesis of PROTACs[1] and also functions as a cleavable 3-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].

Sulfo DBCO-PEG4-Maleimide is a PEGylated derivative with a maleimide group, commonly used as a linker for synthesizing PROteolysis TAgeting Chimeras (PROTACs)[1].

DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker used in the synthesis of PROTACs [1].

DBCO-NHCO-PEG2-maleimide is a polyethylene glycol (PEG) derived PROTAC linker utilized in PROTAC synthesis [1].

DBCO-NHCO-PEG6-maleimide is a polyethylene glycol (PEG)-based linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DSPE-PEG-Maleimide (MW 5000) is a functionalized phospholipid derivative commonly used in the construction of liposomes and nanoparticles. Its terminal maleimide group allows for stable chemical conjugation with thiol-containing biomolecules.

Methyltetrazine-PEG6-maleimide is a PEG-derived linker compound used for synthesizing PROTACs [1].

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in synthesizing antibody-drug conjugates (ADCs) and is essential in producing the ADC compound Gemcitabine-O-Si(di-iso)-O-Mc [1].

TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

TCO-PEG5-maleimide, a PEG-based linker for PROTACs, joins two essential ligands essential for PROTAC molecule formation and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG9-maleimide is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

N-Arachidonyl maleimide, a potent and irreversible monoacylglycerol lipase (MAGL) inhibitor, has an IC50 value of 140 nM [1].

Maleimide-DOTA is a non-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs).

Maleimide-C10-NHS ester is an alkyl/ether-based linker utilized in PROTAC synthesis.

Glutathione maleimide is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.

N-Tetamine-pSar45-Maleimide (N-Tetamine-polySarcosine45-Maleimide) is a pSar-lipid derivative. It serves as a hydrophilic alternative to PEG and is utilized in drug delivery research.

DBCO-PEG3-Maleimide is a PEG derivative composed of DBCO, PEG units, and Maleimide. Maleimide forms stable thioether bonds with thiols (-SH). The DBCO group in DBCO-PEG3-Maleimide enables it to undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.

Biotin-PEAC5-maleimide hydrochloride is a biochemical detection reagent used in biotin-PEAC5-maleimide (BPM) labeling assays to evaluate the modification of protein thiols by electrophilic agents.

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-like PROTAC linker that can be used to synthesize PROTAC molecules.

Alkyne-PEG4-maleimide is a PEG-based bifunctional linker designed for the construction of PROTAC molecules, enabling covalent conjugation between ligand moieties via its terminal alkyne and maleimide groups, and facilitating selective protein degradation through ubiquitin–proteasome system recruitment.

DBCO-Maleimide (DBCO-MAL) is a non-cleavable ADC linker for the synthesis of ADC compounds.

DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions.

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that synthesises PROTAC molecules. Methyltetrazine-PEG4-maleimide contains a Tetrazine moiety and can undergo an iEDDA click with molecules containing a TCO moiety.