less-active — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10480	Bay 41-4109 (less active enantiomer)		HBV
	Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).		HBV
T6352	(-)-Dizocilpine maleate	C13737,(-)-MK 801 (Maleate),(-)-MK 801 Maleate	NMDAR , iGluR
	(-)-Dizocilpine maleate ((-)-MK 801 (Maleate)) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.		NMDAR , iGluR
T20191	(-)-Camphoric acid	L-Camphoric acid,Camphoric acid, (-)-	GluR
	(-)-Camphoric acid (L-Camphoric acid) is a less active enantiomer of Camphoric acid which induces GluR expression.		GluR
T12664	(Rac)-BRD0705		Others
	(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.		Others
T12814	(S)-Tenofovir	(S)-PMPA,(S)-GS 1278,(S)-TDF	Others
	(S)-Tenofovir ((S)-PMPA) is the less active S-enantiomer of Tenofovir which is a nucleotide reverse transcriptase inhibitor.		Others
T13669	(E)-Cinnamamide	trans-Cinnamamide	Others
	(E)-Cinnamamide (trans-Cinnamamide) is the less active isomer of Cinnamamide which is an effective non-lethal chemical repellent suitable for reducing avian pest damage.		Others
T12831	SAR405 R enantiomer		Others
	SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34.		Others
T68051L	RS 15385-198		Adrenergic Receptor
	RS 15385-198 is a less active isomer of Delequamine. Delequamine is a selective alpha2-adrenergic receptor antagonist.		Adrenergic Receptor
T10376	ARS-1630		Ras
	ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.		Ras
T11129L	Duvelisib (R enantiomer) hydrochloride	IPI-145 R enantiomer HCl,Duvelisib (R enantiomer) hydrochloride(1261590-48-0 Free base),INK1197 R enantiomer HCl	PI3K
	Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor. Duvelisib (R enantiomer) hydrochloride is the less active enantiomer of Duvelisib.		PI3K
T6205	AT7519		Apoptosis , GSK-3 , CDK
	AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.		Apoptosis , GSK-3 , CDK
T22818	GSK9027	GR agonist 23a,GSK 9027,GSK-9027	Glucocorticoid Receptor
	GSK9027 (GR agonist 23a) is a nonsteroidal glucocorticoid receptor (GR) agonist.GSK9027 is a partial agonist on the 2×GRE reporter gene compared to dexamethasone and is less active than dexamethasone activity.		Glucocorticoid Receptor
T7080	CCT245737	SRA737	Chk
	CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM).		Chk
T9042	Teriflunomide impurity 3	4-Amino-N-(4-trifluoromethylphenyl)benzamide	COX
	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor(IC50 of 30 μM). It is less active against COX-2 (IC50>100 μM).		COX
T9554	SN-008		STING
	SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.		STING
T22450	Tyrphostin B44, (+) enantiomer		EGFR
	Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer.		EGFR
T16759	Ritanserin	R 55667	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Ritanserin (R 55667) is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.
T67905	GS-829845		JAK , Drug Metabolite
	GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life than the parent.		JAK , Drug Metabolite
T12146	N-Desmethyl-Apalutamide	N-Desmethyl Apalutamide	P450 , Androgen Receptor
	N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.		P450 , Androgen Receptor
T15545	ICA-27243		Potassium Channel
	ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.		Potassium Channel