krp

KRP-109, a neutrophil elastase (NE) inhibitor, acts by decreasing expression of TGF-ß Signal Related Genes.

KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia.

KRP-199, a highly potent and selective antagonist for the AMPA receptors, exhibits good neuroprotective effects in vivo.

KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.

N-5984, a β3-adrenergic receptor agonist, is used potentially for the treatment of obesity, overactive bladder and type 2 diabetes.

Lascufloxacin, a potent and orally active fluoroquinolone antibacterial agent, holds potential for the treatment of various infectious diseases, including lower respiratory tract infections. It effectively inhibits infections caused by a wide range of pathogens, encompassing those resistant to quinolones.

Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).

Lascufloxacin (KRP-AM-1977) is a potent antibacterial drug candidate. It exhibited the most potent activity against gram-positive bacteria among the quinolones tested. Lascufloxacin showed incomplete cross-resistance against existing quinolone-resistant s

Mocravimod is an agonist of sphingosine 1-phosphate receptor type 1. Mocravimod ameliorates atherosclerosis in LDL-R-/- mice. KRP-203 attenuates rat autoimmune myocarditis. KRP-203 combined with cyclosporine prolonged graft survival and abrogated transpla

Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.

Imidafenacin (KRP-197)(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.

Imidafenacin hydrochloride is a highly effective and selective M3 receptor inhibitor with a Kb value of 0.317 nM [1].

KRP-101, a PPARɑ agonist, is used potentially for the treatment of diabetes and hyperlipidaemia.

KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras. This compound is suitable for use in cancer research [1].

KRpep-2d (TFA) is a potent K-Ras inhibitor that effectively impedes the proliferation of K-Ras-driven cancer cells, making it a valuable asset for cancer research [1].

KRPEP-2D acetate was identified as a K-Ras(G12D) selective inhibitory peptide against the G12D mutant of K-Ras, which is a key member of the Ras protein family and an attractive cancer therapeutic target.

AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.

AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).

CD161 is a potent, selective, and orally bioavailable BET bromodomain inhibitor (IC50s: 28.2 nM and 7.2 nM for BRD4 BD1 and BRD4 BD2) with good anticancer activity.

KRP-109 is a neutrophil elastase (NE) inhibitor known for its ability to alleviate lung inflammation. In mouse models, KRP-109 has been shown to increase survival rates and reduce both the number of neutrophils in alveolar walls and the severity of inflammation. It significantly decreases cell and neutrophil counts, along with cytokine levels (such as interleukin 1β and macrophage inflammatory protein 2) in bronchoalveolar lavage fluid. KRP-109 is applicable for investigating severe pneumonia.

Neramexane is an NMDA antagonist with neuroprotective effects. Neramexane has antidepressant and nootropic actions. It also acts as a nicotinic acetylcholine receptor antagonist.

Imidafenacin-D10 is a deuterated compound of Imidafenacin. Imidafenacin (T4986) has a CAS number of 170105-16-5. Imidafenacin (KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM.