k-89

PSMA-1007 is a novel Glu-Ureido-type prostate-specific membrane antigen (PSMA) inhibitor.

MK-8998 is a T-type calcium channel antagonist that may be utilized in the treatment of schizophrenia. However, it has not demonstrated efficacy in treating hospitalized patients with acute psychosis, according to the PANSS scores measured at week four.

GSK-894490A is an agonist of ghrelin receptor. GSK-894490A crosses the blood/brain barrier and elicit pro-cognitive effects.

MK-8970 is an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.

K-8986 is a novel h1-receptor antagonist

MRK-898, an orally active modulator of the GABA(A) receptor, selectively interacts with the α1, α2, α3, and α5 subunits, displaying K i values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. It is noteworthy that the α1-containing receptors of GABA(A) are classified as "sedative," whereas receptors containing α2 and/or α3 are designated as "anxiolytic" subtype(s) [1].

GSK 894281 is a ghrelin receptor agonist. It may produces myocardial degeneration/necrosis in rats.

STK899704 is a tubulin inhibitor. It prevents the polymerization of purified tubulin in vitro and depolymerizes microtubule in cultured cells leading to mitotic arrest.

Suvecaltamide (MK-8998) as potent inhibitors of T-type calcium channels.

BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.

Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.

U-78517F is a potent inhibitor of lipid peroxidation.

Racemic rasagiline, also known as AGN-1135, is a Monoamine Oxidase type-B inhibitor (MAOI). However, application of this drug can lead to fatal hypertensive crisis in patients who consume tyramine-rich foods. TVP-1022 is the (S)-isomer os Rasagiline and acts as a cardioprotective agent.