itf

ITF3756 is a selective HDAC6 inhibitor.

Icrocaptide is used potentially for the treatment of acute myocardial infarction.

Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.

Givinostat (ITF-2357) is an HDAC inhibitor with IC50 values of 198 nM for HDAC1 and 157 nM for HDAC3.

Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor.

Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineoplastic activities.

AZD3229 Tosylate is a highly potent inhibitor targeting mutant forms of the pan-KIT enzyme, with a primary application in the treatment of gastrointestinal stromal tumors (GISTs).

Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.

ITF5924 (compound 1), a potent HDAC6 inhibitor featuring a difluoromethyl-1,3,4-oxadiazole (DFMO) moiety, exhibits an IC 50 of 7.7 nM and surpasses 104-fold selectivity over other HDAC subtypes. As a slow-binding substrate analog of HDAC6, ITF5924 undergoes an enzyme-catalyzed ring opening reaction, resulting in the formation of a stable, long-lasting enzyme-inhibitor complex [1].

FTI-2148 diTFA, a dual inhibitor targeting both farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1), functions as a RAS C-terminal mimetic. It exhibits potent inhibitory capabilities with IC50 values of 1.4 nM for FT-1 and 1.7 μM for GGT-1, respectively.

Dihydrocitflavanone is a useful organic compound for research related to life sciences and the catalog number is T124352.

Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.

NOX2-IN-2 diTFA (compound 33) is an effective inhibitor of NOX2, targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. This compound effectively suppresses the production of ROS generated by NOX2 in cells.

Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist

BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degradation of CDK4/6. It exhibits IC50 values of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1, indicating strong inhibitory capabilities. Notably, it spares IKZF1/3 from degradation and possesses anti-cancer activity [1].

Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.

PROTAC EGFR degrader 7 (compound 13b) is a potent, selective, CRBN-recruiting EGFRL858R/T790M degrader with a DC50 of 13.2 nM. It effectively inhibits NCI-H1975 cell proliferation with an IC50 of 46.82 nM, induces apoptosis, and causes G2/M phase arrest. This compound shows antitumor activity and is applicable in non-small cell lung cancer (NSCLC) research.

Lanreotide (BIM 23014) diTFA, a somatostatin analogue, exhibits antineoplastic activity and may be utilized in carcinoid syndrome research [1] [2].

BIBO3304 (diTFA), a selective neuropeptide Y (NPY) Y1 receptor antagonist, demonstrates oral efficacy. It exhibits high affinity for Y1 receptors in both humans and rats, with IC50 values of 0.38 nM and 0.72 nM, respectively. Additionally, BIBO3304 (diTFA) enhances bone-tendon healing via the Wnt/β-catenin signaling pathway [1] [2] [3].

CITFA, a GPER agonist, enhances neurite outgrowth in rat embryonic (E18) hippocampal neurons [1].

iBRD4-BD1 diTFA is a selective BRD4 bromodomain inhibitor with an IC50 value of 12 nM. It can be used for research in inflammation and oncology [1].

Philanthotoxin 74 (PhTx 74) diTFA acts as an antagonist to AMPAR, specifically inhibiting GluR3 and GluR1 with IC50 values of 263 nM and 296 nM, respectively.

STING agonist-18 diTFA (compound 1a) can be utilized in the synthesis of antibody-drug conjugates (ADCs), such as Trastuzumab conjugates.

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide that can cross the blood-brain barrier and acts as a potent antidepressant, similar to melanocyte suppressor factor (MIF).