hydroxysteroid

Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.

Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, the main and sweet component of licorice, has been studied for its ability to cause hypermineralocorticoidism with potassium loss and sodium retention, edema, increased blood pressure, as well as inhibited the renin-angiotensin-aldosterone system.

11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.

Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.

Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.

3-Acetyl-11-keto-ursolic acid (Compound 18), a triterpenoid derived from Eriobotrya japonica leaves, exhibits inhibitory activity against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and holds potential for anti-diabetes research [1].

11Beta-hydroxyprogesterone (11β-Hydroxyprogesterone) is an inhibitor of 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 2, which activates the human hydrocorticosteroid receptor in COS-7 cells, and may be useful in the study of metabolism-related diseases.

Feigrisolide A is a lactone produced by Streptomyces griseus. It exhibits moderate inhibitory activity against 3α-hydroxysteroid dehydrogenase.

Vibralactones D shows weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).

3-Hydroxylicochalcone A is a naturally occurring chalcone derivative. chalcone derivatives usually inhibit murine 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), e.g., Licochalcone A is the most potent of them all (IC50=15.6 μM).

21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is generated from 11-ketoprogesterone by the cytochrome P450 (CYP) isoform CYP17A1, and can also be produced by oxidation via 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) from 21-deoxycorticosterone. In patients with congenital adrenal hyperplasia, a metabolic disorder characterized by a deficiency of 21-hydroxylase, levels of 21-Deoxy Cortisone are elevated.

Feigrisolide B is a lactone produced by the gray Streptomyces. It exhibits antifungal activity against Trichosporon pullulans and inhibitory effects on Coxsackie virus B3. Additionally, Feigrisolide B has moderate inhibitory activity against 3α-hydroxysteroid dehydrogenase.

Feigrisolide D is a lactone produced by Streptomyces griseus. It exhibits moderate inhibitory activity against 3α-hydroxysteroid dehydrogenase.