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Results for "

hydroxysteroid

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    156
    TargetMol | Inhibitors_Agonists
  • Natural Products
    12
    TargetMol | Natural_Products
  • Recombinant Protein
    19
    TargetMol | Recombinant_Protein
  • Isotope Products
    2
    TargetMol | Isotope_Products
  • Antibody Products
    2
    TargetMol | Antibody_Products
12α-Hydroxysteroid dehydrogenase
T20007761642-40-8
12α-Hydroxysteroid dehydrogenase, an NAD-dependent enzyme expressed in Bacillus sphaericus, actively processes both free and conjugated bile salts. It is utilized to determine the levels of 12α-hydroxy bile acids in serum.
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3α-Hydroxysteroid dehydrogenase
T761479028-56-2
3α-Hydroxysteroid dehydrogenase (3α-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3α-hydroxy compounds. This enzyme significantly contributes to the inactivation of the androgen DHT by converting it into 3α-androstanediol, which exhibits reduced androgen activity. Such conversions are crucial in hirsutism research [1].
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AZD8329
AZD 8329, AZD-8329
T143831048668-70-7In house
AZD8329 is a selective and potent 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that inhibits 11β-HSD2, 17β-HSD1, 17β-HSD3, and can be used for the study of allergic reactions in humans.
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6-8 weeks
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TargetMol
BI-135585
BI135585, BI 135585
T267941114561-85-1In house
BI-135585 is an orally active, selective and potent inhibitor of human 11β-hydroxysteroid dehydrogenase-1 (HSD1) for the study of type 2 diabetes.
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6-8 weeks
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11β-HSD1-IN-11
T60149859721-81-6In house
11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13 μM, respectively. 11β-Hsvd1-in-11 is a compound used as a chemical compound. 11β-HSD1-IN-11 is a hormone involved in regulating various physiological processes, such as metabolism, inflammation, and stress responses. 11β-Hd1-in-11 is a potential compound for the treatment of metabolic disorders, obesity, and certain inflammatory conditions.
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HSD-016
T63569946396-92-5In house
HSD-016 is an orally active, selective and potent type 1 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitor with strong inhibitory effects on human, mouse and rat 11β-HSD1.HSD-016 can be used in the study of diabetes and metabolic syndrome.
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6-8 weeks
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11β-HSD1 inibitor 17
T67903946394-50-9In house
11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).
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Epostane
Win-32729
T6866480471-63-2In house
Epostane acts as an antiprogestogen and terminates pregnancy by inhibiting 3β-hydroxysteroid dehydrogenase and preventing the biosynthesis of progesterone and pregnenolone. [4]
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6-8 weeks
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BMS-823778
T713941140897-32-0In house
BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.
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6-8 weeks
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Diammonium Glycyrrhizinate
Diammonium Glycyrrhizin
T052279165-06-3
Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, the main and sweet component of licorice, has been studied for its ability to cause hypermineralocorticoidism with potassium loss and sodium retention, edema, increased blood pressure, as well as inhibited the renin-angiotensin-aldosterone system.
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Trilostane
Win 24540
T147313647-35-3
Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.
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Adrenosterone
11-ketoandrostenedione, 11-oxoandrostenedione, Reichstein's substance G
T2207382-45-6
Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.
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7-Amino-4-(trifluoromethyl)coumarin
Coumarin 151, AFC
TJS034153518-15-3
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist, a Galanin Receptor 2 (GALR2) antagonist, and a hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) inhibitor with an activity value of 21 µM.
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2-(Acetyloxy)-3-Methylbenzoic Acid
T02384386-39-4
2-(Acetyloxy)-3-Methylbenzoic Acid is used in qHTS Assay for Inhibitors of hydroxysteroid (17-beta) dehydrogenase 4, HSD17B4 with activity value of 19.95 μM
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TC HSD 21
T13100330203-01-5
TC HSD 21 is a potent and highly selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (IC50 = 14 nM).
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PF-915275
T16510857290-04-1
The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF-915275 is an effective and selective human 11β-hydroxysteroid dehydrogenase type 1 inhibitor
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6-8 weeks
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WEHL-04
7-Bromo-1,2,3,4-tetrahydroquinoline
T22458114744-51-3
WEHL-04 is an intermediate used to prepare (isoquinolinylsulfonyl)benzoic acids as inhibitors of type 5 71-β-hydroxysteroid dehydrogenase AKR1C3. It is also used in the synthesis of 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists
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WAY-311610
T77606314051-55-3
WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pain, inflammatory pain, and occipital neuralgia.
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D4-abiraterone
Δ4-Abiraterone, Delta4-Abiraterone, CB-7627, CB7627, Abiraterone D4A metabolite
T10946154229-21-7
D4-abiraterone is the active metabolite of abiraterone produced by 3β-HSD and is further metabolised by SRD5A.Δ4-Abiraterone is an inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.
    7-10 days
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    (Rac)-BMS-816336
    T12663
    (Rac)-BMS-816336 (Compound 6n), a racemate of BMS-816336, is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 values of 10 nM and 68 nM, respectively, and demonstrates good metabolic stability [1].
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    3-6 months
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    11-Beta-hydroxyandrostenedione
    NSC-17102, 4-Androsten-11β-ol-3,17-dione
    T14001382-44-5
    11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.
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    AKR1C1-IN-1
    T141514906-68-7
    AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase (AKR1C1) inhibitor (Ki: 4 nM for AKR1C1).
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    AZD 4017
    T143881024033-43-9
    AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
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    6-8 weeks
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    Tetrahydrocortisol
    Tetrahydrohydrocortisone
    T1705753-02-1
    Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.
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