gpr91

hGPR91 antagonist 3 is an orally active, potent, and selective hGPR91 antagonist. hGPR91 antagonist 3 is used to study hypertension, autoimmune diseases, and retinal angiogenesis. hGPR91 antagonist 3 has been shown to be effective in the treatment of hypertension, autoimmune disease, and retinal angiogenesis.

NF-56-EJ40 is an effective and highly selective antagonist of human SUCNR1 with an IC50 of 25 nM and a Ki of 33 nM.

hGPR91 antagonist 1 is a potent and selective hGPR91 antagonist (IC50: 7 nM).

NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 hydrochloride has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.

Succinate calcium is a crucial intermediate in the citric acid cycle (tricarboxylic acid cycle). It serves as a specific ligand for the G protein-coupled receptor GPR91. Additionally, succinate calcium can enhance the amplitude of calcium transients in cardiomyocytes and expedite their decay. Furthermore, it can induce myocardial apoptosis (apoptosis).

cis-Epoxysuccinic acid is a potential agonist of Succinate receptor 1 and inhibitor of Isocitrate lyase 1 for use in biochemical experiments.