ganoderic

Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum

Ganoderic acid R, exhibiting notable anticancer properties, effectively hampers tumor growth through apoptosis induction in both multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and sensitive tumor cell line (KB-A-1), demonstrating significant cytotoxicity.

Ganoderic acid GS-1, an extensively oxygenated lanostane-type triterpenoid, exhibits anti-HIV-1 protease activities, displaying an IC50 value of 58 μM [1].

Ganoderic acid Df, a lanostane-type triterpenoid isolated from the fruiting body of Ganoderma lucidum, potently inhibits aldose reductase with an IC 50 of 22.8 ± 0.6 μM [1].

Ganoderic acid Mk (GA-Mk), a triterpenoid acid derived from Ganoderma lucidum mycelia, exhibits potent anti-proliferative properties and can induce apoptosis in HeLa cells through a mitochondria-mediated pathway, making it significant for cervical cancer research [1] [2].

Ganoderic acid Mf, an antitumor triterpenoid, selectively induces apoptosis in cancer cells through a mitochondria-mediated pathway while demonstrating high selectivity between normal and cancer cells. It also arrests the cell cycle in the G1 phase [1].

Ganoderic acid T1, a deacetylated derivative of Ganoderic acid T, diminishes mitochondrial membrane potential and triggers cell apoptosis by activating caspase-9 and caspase-3, thus impairing the antioxidant defense system of cancer cells. Additionally, it elevates intracellular ROS levels, yielding pro-oxidant activities and cytotoxicity [1].

Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1].

Ganoderic acid T, a natural compound isolated from Ganoderma lucidum [1], exhibits various pharmacological properties.

Ganoderic acid Me, a triterpenoid present in Ganoderma lucidum [1], exhibits various biological activities.

Ganoderic acid U is a substance known for its antitumor properties.

Ganoderic acid W is a compound known for its antitumor properties.

Ganoderic acid Y significantly inhibits the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating.

Ganoderic acid AM1 treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.8+/-0.7 microM.

Ganoderic acid K is an angiotensin-converting enzyme inhibitor. It has anti-tumor, and anti-inflammatory activities.

Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs.

Ganoderic acid TN is a natural product. The catalog number is TN4106 and the CAS number is 112430-64-5. Ganoderic acid TN can be used as a reference standard.

Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.

Ganoderic acid L is a natural product from the fruiting body of the fungus Ganoderma lucidum (Reishi).

Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidases (NAs), particularly H1N1 and H5N1 neuraminidases, with IC50 values of 4.6 and 10.9 μM, respectively.

Ganoderic acid M is a useful organic compound for research related to life sciences and the catalog number is T126539.

Ganoderic acid beta is a constituent from the fruiting body of Ganoderma lucidum (Fr.) Karst].

Ganoderic acid J is a natural lanostane-type triterpenoid isolated from the medicinal fungus Ganoderma lucidum. Since its initial characterization in 1985, Ganoderic acid J has been identified as a bioactive constituent with potent anti-inflammatory activity. As a representative member of the ganoderic acid family, it plays a critical role in modulating immune cell responses and mitigating inflammation. It serves as a significant molecular probe for investigating the pharmacological mechanisms of fungal secondary metabolites in inflammatory diseases

Ganoderic acid G is isolated from the surface of Ganoderma lucidum tube layer.