diterpenoid

1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.

Rosthornin A is a kind of natural product derived from the herbs of Rabdosia rosthornii.

Trichorabdal A shows a very strong in vitro antibacterial activity against Helicobacter pylori.

Peniditerpenoid A is a bicyclic indole diterpene. It can reduce the expression of RANKL-induced p-IkBα and inhibit RANKL-induced osteoclast differentiation. Peniditerpenoid A holds potential for osteoporosis research.

Lasiodonin is a natural product isolated from the leaves of Isodon parvifolius.

Lophanthoidin E is a kind of natural product derived from the herbs of Rabdosia lophanthoides.

Agastaquinone, as a diterpenoid quinone, may have nonspecific cytotoxic activities against several human cancer cell lines in vitro.

Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

Tiamulin fumarate (Thiamutilin fumarate) is a semisynthetic diterpenoid antibiotic with antibacterial activity and inhibition of protein synthesis, which can be used to study pneumocystis.

Kauran-16,17-diol, a natural diterpenoid product, exhibits anti-tumoral and apoptosis-inducing activities by inhibiting NO production in LPS-induced RAW 264.7 cells with an IC50 value of 17 μM.

Ranaconitine is an important diterpenoid alkaloid from Aconitum sinomontanum Nakai,ranaconitine has cardiotoxicity.

8-Deacetylyunaconitine is a a diterpenoid alkaloid derived from Aconitum Vilmorinian Radix.

Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).

Triptonoterpene is a natural product found in Tripterygium wilfordii and Tripterygium doianum. Triptonoterpene is an abietane diterpenoid.

Penitrem A is an indole-diterpenoid neurotoxic alkaloid produced by *Penicillium* species. As a selective BK channel antagonist, it exhibits antiproliferative and anti-invasive activities against various malignancies, and stimulates the spontaneous release of endogenous glutamate, GABA, and aspartate from cortical synaptosomes. It is commonly used to induce tremor models in animals.

Ryanodine, a diterpenoid poison derived from Ryania speciosa, acts as a modulator of the ryanodine receptor, which is permeable to cells. Depending on its concentration, ryanodine can either stimulate or inhibit Ca2+ release mediated by these receptors.

Pseudolaric Acid C2 is a diterpenoid isolated from Pseudolarix kaempferi.

Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.

Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.

Jatrophone is a novel inhibitor of the macrocyclic diterpenoid tumor.

Rabdosin A is a diterpenoid antitumor constituent from Rabdosia japonica.

Ajugamarin A 1 is a Neoclerodane diterpenoid.

Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens that exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicidin induces apoptosis of gastric carcinoma cells, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on the protein levels of JAK2 and STAT3.