diclofenac

Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.

Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.

Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).

Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

4'-Hydroxydiclofenac is a diclofenac metabolite.

Diclofenac Epolamine (DHEP) is a non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic actions.

Diclofenac-D4 (Standard) is a reference standard of Diclofenac-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Diclofenac-d4 is a deuterated compound of Diclofenac. Diclofenac has a CAS number of 15307-86-5. Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.

Diclofenac deanol is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many traditional NSAIDs, diclofenac inhibits cyclooxygenase (COX)-2 enzyme with greater potency than it does COX-1.

4'-Hydroxy Diclofenac-D4 (Major) is a deuterated compound of 4'-Hydroxy Diclofenac (T19819). 4’-Hydroxy Diclofenac has a CAS number of 64118-84-9. 4'-Hydroxydiclofenac is a diclofenac metabolite.

Diclofenac Amide is used as a intermediates of Diclofenac.

Diclofenac ethyl ester can be used in related research in the field of life sciences. Its product number is T37481 and CAS number is 15307-77-4.

5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 μM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.

Diclofenac-D4 sodium is the deuterated form of Diclofenac sodium (T1555). Diclofenac Sodium (GP 45840) is an effective, non-selective anti-inflammatory agent that acts as a COX inhibitor, with IC50 values of 4 nM for human COX-1 and 1.3 nM for COX-2 in CHO cells. For sheep COX-1 and COX-2, the IC50 values are 5.1 μM and 0.84 μM, respectively. Diclofenac Sodium induces apoptosis in neural stem cells by activating the caspase cascade [apoptosis].

Diclofenac-13C6 is a 13C6-labeled form of Diclofenac. Diclofenac (T0196) acts as a potent, non-selective anti-inflammatory agent and functions as an inhibitor of COX enzymes. In CHO cells, it has IC50 values of 4 nM for human COX-1 and 1.3 nM for COX-2. Additionally, Diclofenac (T0196) exhibits IC50 values of 5.1 μM for sheep COX-1 and 0.84 μM for COX-2. Dic...

Diclofenac-D4 is a deuterated compound of Diclofenac. Diclofenac (T0196) has a CAS number of 15307-86-5. Diclofenac (T0196) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac (T0196) binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.

4'-Hydroxy Diclofenac-D4 is a deuterated compound of 4'-Hydroxy Diclofenac (T19819) for isotope tracing. 4'-Hydroxy Diclofenac (T19819) is a CYP2C9-generated metabolite of Diclofenac with oral bioavailability, anti-inflammatory effects, and analgesic properties.

Diclofenac (Standard) is the standard substance of Diclofenac, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.

Diclofenac sodium (Standard) is the reference standard of diclofenac sodium, suitable for quantitative analysis, quality control, biochemical experiments, and related research. Diclofenac sodium is a non-selective anti-inflammatory drug and a cyclooxygenase (COX) inhibitor. In CHO cells, its IC₅₀ values against human COX-1 and COX-2 are 4 nM and 1.3 nM, respectively; against ovine COX-1 and COX-2, they are 5.1 μM and 0.84 μM, respectively. In addition, diclofenac sodium induces apoptosis in neural stem cells by activating the caspase cascade.

Diclofenac-[Ring-13C6] (Standard) is a reference standard of Diclofenac-[Ring-13C6] intended for quantitative analysis, quality control, and related biochemical research applications.

Diclofenac methyl ester is a hydrophobic prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac . It is more soluble than diclofenac acid in isopropylmyristate. Diclofenac methyl ester does not permeate human epidermal membranes in vitro.

4'-Hydroxydiclofenac-[13C6] (Standard) is a reference standard of 4'-Hydroxydiclofenac-[13C6] intended for quantitative analysis, quality control, and related biochemical research applications.

2,6-Dichlorodiphenylamine, an analogue of Diclofenac Sodium, exhibits anti-Candida albicans activity. Diclofenac Sodium, a potent and nonselective COX inhibitor, has IC50 values of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. [1]. Makoto Urai, et al. Potent Drugs That Attenuate anti-Candida albicans Activity of Fluconazole and Their Possible Mechanisms of Action. J Infect Chemother. 2014 Oct;20(10):612-5.

S-Diclofenac is a novel NSAID formed by linking diclofenac to an H2S-releasing moiety. S-Diclofenac spares the gastric mucosa of injury despite markedly suppressing prostaglandin synthesis [1].