dermatological

Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet aggregation and improves blood flow by increasing erythrocyte and leukocyte flexibility.

Lanopepden (GSK 1322322) is a potent peptide deformylase inhibitor effective against Staphylococcus aureus strains ATCC 29213 and ATCC 25923, and is applicable in the study of pneumonia, dermatological, and infectious diseases.

Allantoin (Glyoxyldiureide), a urea hydantoin found in urine and plants, is used in dermatological preparations.

Dicaprylyl carbonate (Dimethyl carbonate) is a solid fat derived from plants and a dry emollient. Dimethyl carbonate has good skin compatibility and comprehensive properties, such as a sunscreen filter with the ability to dissolve and disperse.

AN3485 Hydrochloride is a novel anti-inflammatory agent and Toll-like receptor (TLR) inhibitor. It can reduce PMA-induced ear swelling and is used in dermatological research.

Hydrocortisone buteprate is a medium-potent, non-halogenated double-ester derivative of hydrocortisone that has researches indicate highly favorable benefit-to-risk ratio in inflammatory dermatological disorders.

(Z)-Viaminate, a derivative of Retinoic acid, exhibits significant biological activity and is frequently used in pharmaceutical and dermatological applications [Ref. 1].

AN0128 (CRM-0005) is an anti-inflammatory boron-containing antibacterial agent that inhibits S. aureus, S. epidermidis, P. acnes, B. subtilis, and suppresses pro-inflammatory cytokine production in macrophage cell lines by inhibiting the p38 MAP kinase signaling pathway. It can be used in dermatological research.

Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.

LEO-29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor, which may be potentially useful for treatment of dermatological diseases. LEO 29102 shows properties suitable for patient-friendly formulations giving efficient drug delivery to the skin. LEO-29102 has reached phase 2 and demonstrated clinically relevant efficacy in the treatment of atopic dermatitis.

Tyrosinase-IN-7 is a potent small-molecule inhibitor of tyrosinase, with an IC50 value of 1.57 μM. Tyrosinase-IN-7 inhibits melanin-related enzymatic activity and exhibits suppression of cell growth while maintaining minimal cytotoxicity. Tyrosinase-IN-7 serves as a valuable tool compound in pigmentation, dermatological, and cancer research.

Etretinate (Standard) is the standard substance of Etretinate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.