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Search Result

Search Results for " conductance "

Targets

CFTR Autophagy

78

Compounds

3

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T3135 KM11060 CFTR , Autophagy
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.
T1805 Ataluren PTC124 CFTR , Autophagy
Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...
T1634 Glibenclamide Glyburide Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T9499 Icenticaftor QBW251 CFTR
Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.
T16681 Nesolicaftor PTI-428 CFTR , Autophagy
Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.
T14935 Elexacaftor VX-445 CFTR , Autophagy
Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.
T5312 CFTR corrector 2 FDL169 CFTR , Autophagy
CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.
T1874 PPQ-102 PPQ102,CFTR Inhibitor,PPQ 102 CFTR , Autophagy
PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
T2588 Ivacaftor Ivacaftor (VX-770),VX-770 CFTR , Autophagy
Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T2451 GlyH-101 GlyH 101 CFTR , Autophagy
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
T10591 BPO-27 racemate BPO-27 (racemate) CFTR , Autophagy
BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.
T7083 GLPG1837 ABBV-974 CFTR , Autophagy
GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T2486 IOWH-032 IOWH032,IOWH 032 CFTR , Autophagy
IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
T9522 Rimtuzalcap CAD-1883 Potassium Channel
Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spin...
T2595 Lumacaftor VX-809,VRT 826809 CFTR , Autophagy
Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
T2355 CFTR(inh)-172 CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172 CFTR , Autophagy
CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.
T2263 Tezacaftor VX661 CFTR , Autophagy
Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
T20341 DNDS CFTR
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
T23471 TRAM 39 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile,TRAM-39,ZINC27105797,2-(2-chlorophenyl)-2,2-diphenylacetonitrile Potassium Channel
TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.
T7512 BMS-191011 BMS-A Potassium Channel
BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models
T4612 NS309 EGFR , Potassium Channel , HER
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...
T63806 CFTR corrector 8 CFTR
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic...
TP1932L1 [D-Trp7,9,10]-Substance P acetate Others
[D-Trp7,9,10]-Substance P acetate is an analogue of substance P which inhibits ion conductance through nicotinic acetylcholine receptors.
T6186 TRAM-34 Triarylmethane-34,TRAM 34 Potassium Channel , IκB/IKK
TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450. The selective activity of TRAM-34(TRA...
T16346 NS1652 Chloride channel
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
T12256 NS8593 hydrochloride NS8593 HCl Potassium Channel
NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
T26955 Cavosonstat N91115,N 91115,N-91115 GSNOR , CFTR
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization.Cavosonstat ...
T4294 NS 11021 NS11021 Potassium Channel
NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels
T60653 CFTR corrector 9 CFTR
CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1].
T30293 Bamocaftor VX-659 CFTR
Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of c...
T10776 CFTR corrector 4 CFTR
CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface a...
T10977 DCEBIO Potassium Channel
DCEBIO stimulates the secretion of Cl- through the activation of the hIK1 K + channel and the activation of the apical Cl- conductance. DCEBIO is a derivative of 1-EBIO and a very strong activator of Cl- secretion by T84...
T16345 NS13001 N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine,N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine Potassium Channel
NS13001 (N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine) is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium ch...
T19658 Enflurane NSC115944,Ethrane,NSC-115944,Efrane,NSC 115944 Others
Enflurane (Efrane), a volatile anaesthetic, is a potent inhibitor of high conductance Ca2+-activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by he...
T15286 Flindokalner BMS-204352 Potassium Channel
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p...
T0782 Benzthiazide Aquatag,Lemazide,Dihydrex Carbonic Anhydrase
Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ...
T25446 Gea 857 Gea857,Gea-857
Gea 857 is a potassium conductance putative blocker.
T24137 HENA
HENA is a novel activator of large conductance, voltage- and Ca2+-gated K+ (BK) channels.
T28195 NS004 NS 004,NS-004
NS004 is a large-conductance K+ channel opener, it inhibits mitochondrial function in glioma cells.
T13705 GLPG2451 Cysteine Protease
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM).
T71599 AqB007
AqB007 is a selective blocker of the Aquaporin-1 ion channel conductance, thereby slowing cancer cell migration.
TP2014 Iberiotoxin
Selective blocker of the big conductance Ca2+-activated K+ channel.
T40650 Dihydroisopimaric acid
Dihydroisopimaric acid activates BK channels alphabeta1, which are large conductance Ca 2+ activated K + channels. This compound directly measures the opening of BKalphabeta1 under a whole-cell voltage clamp.
T29040 UCCF-029 UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029
UCCF-029 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR).
T24004 Ditran
Ditran is an agent of anticholinergic. It also blocking end-plate ion conductance.
T25757 Lorcainide hydrochloride Ro 13-1042,EINECS 261-504-6,Lorcainide HCl,Lopantrol,R 15889
Lorcainide hydrochloride is an antiarrhythmic drug with local anesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Lorcainide appears effective in suppre...
T23648 AF-2785
In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.
TP1431 Chlorotoxin
Chlorotoxin is a 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus) which blocks small-conductance chloride channels.
T27098 Ivacaftor-D9 deutivacaftor,CTP-656
CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
T71598 AqB011
AqB011 is a selective blocker of the Aquaporin-1 ion channel conductance, slowing cancer cell migration.

Compounds

KM11060
T3135
Synonym:
Target: CFTR, Autophagy
Ataluren
T1805
Synonym: PTC124
Target: CFTR, Autophagy
Glibenclamide
T1634
Synonym: Glyburide
Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy
Icenticaftor
T9499
Synonym: QBW251
Target: CFTR
Nesolicaftor
T16681
Synonym: PTI-428
Target: CFTR, Autophagy
Elexacaftor
T14935
Synonym: VX-445
Target: CFTR, Autophagy
CFTR corrector 2
T5312
Synonym: FDL169
Target: CFTR, Autophagy
PPQ-102
T1874
Synonym: PPQ102,CFTR Inhibitor,PPQ 102
Target: CFTR, Autophagy
Ivacaftor
T2588
Synonym: Ivacaftor (VX-770),VX-770
Target: CFTR, Autophagy
GlyH-101
T2451
Synonym: GlyH 101
Target: CFTR, Autophagy
BPO-27 racemate
T10591
Synonym: BPO-27 (racemate)
Target: CFTR, Autophagy
GLPG1837
T7083
Synonym: ABBV-974
Target: CFTR, Autophagy
IOWH-032
T2486
Synonym: IOWH032,IOWH 032
Target: CFTR, Autophagy
Rimtuzalcap
T9522
Synonym: CAD-1883
Target: Potassium Channel
Lumacaftor
T2595
Synonym: VX-809,VRT 826809
Target: CFTR, Autophagy
CFTR(inh)-172
T2355
Synonym: CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172
Target: CFTR, Autophagy
Tezacaftor
T2263
Synonym: VX661
Target: CFTR, Autophagy
DNDS
T20341
Synonym:
Target: CFTR
TRAM 39
T23471
Synonym: 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile,TRAM-39,ZINC27105797,2-(2-chlorophenyl)-2,2-diphenylacetonitrile
Target: Potassium Channel
BMS-191011
T7512
Synonym: BMS-A
Target: Potassium Channel
NS309
T4612
Synonym:
Target: EGFR, Potassium Channel, HER
CFTR corrector 8
T63806
Synonym:
Target: CFTR
[D-Trp7,9,10]-Substance P acetate
TP1932L1
Synonym:
Target: Others
TRAM-34
T6186
Synonym: Triarylmethane-34,TRAM 34
Target: Potassium Channel, IκB/IKK
NS1652
T16346
Synonym:
Target: Chloride channel
NS8593 hydrochloride
T12256
Synonym: NS8593 HCl
Target: Potassium Channel
Cavosonstat
T26955
Synonym: N91115,N 91115,N-91115
Target: GSNOR, CFTR
NS 11021
T4294
Synonym: NS11021
Target: Potassium Channel
CFTR corrector 9
T60653
Synonym:
Target: CFTR
Bamocaftor
T30293
Synonym: VX-659
Target: CFTR
CFTR corrector 4
T10776
Synonym:
Target: CFTR
DCEBIO
T10977
Synonym:
Target: Potassium Channel
NS13001
T16345
Synonym: N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine,N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine
Target: Potassium Channel
Enflurane
T19658
Synonym: NSC115944,Ethrane,NSC-115944,Efrane,NSC 115944
Target: Others
Flindokalner
T15286
Synonym: BMS-204352
Target: Potassium Channel
Benzthiazide
T0782
Synonym: Aquatag,Lemazide,Dihydrex
Target: Carbonic Anhydrase
Gea 857
T25446
Synonym: Gea857,Gea-857
Target:
HENA
T24137
Synonym:
Target:
NS004
T28195
Synonym: NS 004,NS-004
Target:
GLPG2451
T13705
Synonym:
Target: Cysteine Protease
AqB007
T71599
Synonym:
Target:
Iberiotoxin
TP2014
Synonym:
Target:
Dihydroisopimaric acid
T40650
Synonym:
Target:
UCCF-029
T29040
Synonym: UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029
Target:
Ditran
T24004
Synonym:
Target:
Lorcainide hydrochloride
T25757
Synonym: Ro 13-1042,EINECS 261-504-6,Lorcainide HCl,Lopantrol,R 15889
Target:
AF-2785
T23648
Synonym:
Target:
Chlorotoxin
TP1431
Synonym:
Target:
Ivacaftor-D9
T27098
Synonym: deutivacaftor,CTP-656
Target:
AqB011
T71598
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T5065 GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD Monosodium-GMP,cGMP sodium salt,Cyclic GMP PKA
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, inc...
T10278 Alamethicin Others
Alamethicin is isolated from Trichoderma viride. It is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes.
T73764 L-Palmitoylcarnitine TFA
L-Palmitoylcarnitine TFA, a long-chain acylcarnitine and fatty acid metabolite, accumulates in the sarcolemma, disrupting the membrane lipid environment during ischemia. It inhibits K ATP channel activity by interacting ...

Natural Products

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD
T5065
Synonym: Monosodium-GMP,cGMP sodium salt,Cyclic GMP
Target: PKA
Alamethicin
T10278
Synonym:
Target: Others
L-Palmitoylcarnitine TFA
T73764
Synonym:
Target:

Recombinant Proteins

Species：
E. coli (1)
Human (1)
Mycobacterium smegmatis (1)
Rabbit (1)
Expression System：
E. coli (2)
HEK293 (1)
in vitro E. coli expression system (1)
Tag：
N-terminal 10xHis-tagged (2)
His (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPH-03209 CLNS1A Protein, Rabbit, Recombinant (His & Myc) Rabbit E. coli
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blo...
TMPY-03629 Syntaxin 8 Protein, Human, Recombinant (His) Human HEK293
STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated...
TMPH-02998 Porin MspA Protein, Mycobacterium smegmatis, Recombinant (His) Mycobacterium smegmatis E. coli
The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Pl...
TMPH-00698 OmpA Protein, E. coli, Recombinant (His) E. coli in vitro E. coli expression system
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to environmental stress, and a role in outer membrane functionality and c...
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