candidiasis

Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate) is a broad-spectrum antifungal agent approved in Japan for treating onychomycosis, a fungal nail infection. It is a prodrug converted into ravuconazole.

Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine hydrochloride , a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Rezafungin (SP-3025, Biafungin) is a natural product echinocandin and a 1,3-β-D-glucan synthase inhibitor with broad-spectrum antifungal activity, high tissue penetration, and a long half-life, used for the treatment of candidemia and invasive candidiasis.

Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, skin and musculoskeletal disorders, and can be used in the study of vulvovaginal candidiasis, Chagas disease and genitourinary disorders.

Multifungin (Bromochlorosalicylanilide) is an antifungal agent used in studies of oral candidiasis, reducing fungal populations in stored corn and preventing zearalenone formation and accumulation.

Fluconazole (UK-49858) belongs to the triazole class of antifungal agents and is a CYP51 inhibitor (IC99 = 0.20–0.39 μg/mL against Candida albicans), possessing broad-spectrum antifungal activity, good oral absorption, and cell permeability. This compound is used for the treatment of various invasive fungal infections.

Nystatin (Fungicidin) is a topical and oral antifungal agent with activity against many species of yeast and candida albicans, which is used largely to treat skin and oropharyngeal candidiasis.

P-113 acetate is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5, shows good safety and efficacy profiles in gingivitis and human immunodeficiency virus (HIV) patients with oral candidiasis.

Chlordantoin is an antifungal agent with the potential for vaginal candidiasis treatment.

Inz-5 is a small-molecule inhibitor of the mitochondrial electron transport chain that selectively targets mitochondrial complex III (cytochrome bc1 complex), disrupting the process of oxidative phosphorylation and reducing ATP production. It is commonly used in studies of mitochondrial energy metabolism, fungal respiration, and mechanisms related to the electron transport chain. Inz-5 exhibits antifungal activity against a variety of fungal pathogens, demonstrating particularly strong inhibitory effects against Candida species associated with candidiasis; in some studies, its minimum inhibitory concentration (MIC) against Candida albicans reached the sub-micromolar range (approximately 0.5 μM). Furthermore, as an inhibitor of mitochondrial oxidative phosphorylation, Inz-5 is also used to study mechanisms related to tumor cell metabolism and mitochondrial function.

CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.

Antifungalagent 140 (compound 5p) is a potent broad-spectrum antifungal agent. It functions by targeting the Ras/cAMP/PKA pathway to inhibit hyphal formation and ergosterol biosynthesis, offering a dual mechanism of action. In a murine model of systemic candidiasis, Antifungalagent 140 enhances survival rates, reduces renal fungal burden, and boosts host immune response. It is valuable for studying drug-resistant fungal infections.

PA36-2 is an Mdr1 inhibitor and an azole resistance reversal agent, exhibiting an IC50 of 1.0 μg/mL and a Kd of 4.209 μM against Candida albicans Mdr1. By effectively inhibiting the activity of the Mdr1 efflux pump, PA36-2 prevents the expulsion of substrates from cells, thereby enhancing the intracellular accumulation of azole antibiotics. This compound can act synergistically with antifungals such as Fluconazole (FLC) and is useful for research on azole-resistant candidiasis.

P-gp-IN-34 (compound 4a) is an inhibitor of Mdr1p (Mdr1 pump) that suppresses the yeast-to-hyphal transition in Candida albicans. This compound is applicable in the research of candidiasis[1].

Candicidin is an antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic is composed of candicidins A, B, C, and D, of which D is the major component.

CYP51/HDAC-IN-1 is an orally active, potent, dual CYP51/HDAC inhibitor that inhibits important virulence factors and down-regulates the expression of associated drug resistance genes.CYP51/HDAC-IN-1 has shown effective therapeutic effects in both Candidiasis tropicalis and Cryptococcal meningitis.

Antibacterial Agent 84, an antifungal compound, effectively inhibits candidiasis through a CNB1-dependent mechanism and reduces the viability of the C. albicans biofilm [1].

Antifungal agent 73 (compound A32) effectively combats azole-resistant candidiasis by disrupting the fungal cell wall and membrane, demonstrating potent in vivo activity against pathogenic fungi, including fluconazole-resistant strains [1].

Efungumab, a monoclonal antibody exhibiting antifungal properties, specifically targets HSP 90 to inhibit a conformational alteration crucial for fungal survival. It is employed in investigations concerning invasive candidiasis (IC) [1].

Fluconazole-D4 is a deuterated compound of Fluconazole. Fluconazole (T1388) has a CAS number of 86386-73-4. Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.

Fluconazole (Standard) is the standard substance of Fluconazole, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Fluconazole is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.

Fluconazole-D4 (Standard) is a reference standard of Fluconazole-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Fluconazole-d4 is a deuterated compound of Fluconazole. Fluconazole has a CAS number of 86386-73-4. Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.

Ezomycin A2 is an antifungal antibiotic. It is primarily effective against plant pathogens such as Sclerotinia and Botrytis, showing efficacy in controlling crop diseases like sclerotinia rot, botrytis blight, and candidiasis.

Ezomycin A1 is an antifungal antibiotic effective primarily against plant pathogens such as Sclerotinia and Botrytis. It is used to prevent and control diseases like Sclerotinia rot, gray mold, and candidiasis in crops.