bacterial rna polymerase

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.

Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.

Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth.

Acyclovir (Aciclovir) is a guanine analog and orally active antiviral agent characterized by a narrow antiviral spectrum, high selectivity, and low toxicity. Acyclovir exhibits activity against HSV-1 (IC50 = 0.85 μM), HSV-2 (IC50 = 0.86 μM), and varicella-zoster virus. Acyclovir can be used for herpesvirus treatment research.

Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.

Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.

Rifamycin sodium (Rifamycin sodium salt) salt is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase. It is effective against Gram-positive bacteria.

Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent, acute liver injury.

Pseudouridimycin is a C-nucleoside analogue. Pseudouridimycin is an antibiotic and is a selective bacterial RNA polymerase (RNAP) inhibitor. It is effective against both Gram-negative and Gram-positive bacteria.

Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.

Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki: 18 μM and a Kd: 15 μM).

RNA polymerase-IN-3 is an inhibitor of bacterial RNA polymerase (RNAP) with antimicrobial properties. It suppresses RNA synthesis by competitively blocking UTP from binding to RNAP, with an inhibitory concentration (IC50) of 0.28 μM. RNA polymerase-IN-3 holds potential for research into bacterial infections.

RNAP-σ interaction-IN-4 (Compound 3a) is an inhibitor of the interaction between RNA polymerase and the sigma factor (RNAP-σ). It has a minimum inhibitory concentration (MIC) of 1 μg/mL against S. pneumoniae and 2 μg/mL against S. aureus. This compound exhibits potent bactericidal properties by disrupting bacterial transcription through interference with the β′CH−σ interaction. Additionally, RNAP-IN-2 has demonstrated significant efficacy in a sepsis model. RNAP-σ interaction-IN-4 is applicable for studying Gram-positive bacterial infections involving multidrug-resistant strains.

Myxopyronin A is an inhibitor of bacterial RNA polymerase.

Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.

Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.

Rifabutin-D7 is a deuterated compound of Rifabutin. Rifabutin (T1501) has a CAS number of 72559-06-9. Rifabutin (T1501) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin (T1501) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

Rifaximin-D6 is a deuterated compound of Rifaximin. Rifaximin (T1154) has a CAS number of 80621-81-4. Rifaximin (T1154) is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin (T1154) binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth.

Rifampicin-D8 is a deuterium-labelled compound of rifampicin, which can be used for isotope tracing. Rifampicin (T0681) is a broad-spectrum antibiotic that primarily exerts its antibacterial activity by inhibiting bacterial DNA-dependent RNA polymerase.

Rifaximin (Standard) is the standard substance of Rifaximin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth.

Rifabutin (Standard) is a reference standard for research and analysis in studies involving Rifabutin. Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

Rifampicin-D8 (Standard) is a reference standard of Rifampicin-D8 intended for quantitative analysis, quality control, and related biochemical research applications. Rifampicin-d8 is a deuterium-labelled compound of rifampicin, which can be used for isotope tracing. Rifampicin is a broad-spectrum antibiotic that primarily exerts its antibacterial activity by inhibiting bacterial DNA-dependent RNA polymerase.

Rifaximin-D6 (Standard) is a reference standard of Rifaximin-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Rifaximin-d6 is a deuterated compound of Rifaximin. Rifaximin has a CAS number of 80621-81-4. Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth.