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Results for "

bace2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    16
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    2
    TargetMol | Recombinant_Protein
bace2-in-1
T730981676107-08-6
BACE2-IN-1, a potent BACE2 inhibitor characterized by its exceptional selectivity and a Ki value of 1.6 nM, is utilized in the investigation of Type 2 Diabetes.
  • Inquiry Price
6-8 weeks
Size
QTY
LY2886721
T60581262036-50-9
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
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TargetMol | Inhibitor Sale
AM-6494
T102921874232-80-0
AM-6494, a potent and orally active BACE1 inhibitor (IC50: 0.4 nM), exhibits in vivo selectivity over BACE2 (IC50: 18.6 nM).
  • Inquiry Price
3-6 months
Size
QTY
BACE1-IN-1
T104501310347-50-2
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
  • Inquiry Price
8-10 weeks
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QTY
BACE1-IN-4
T104522361157-92-6
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), exhibiting greater selectivity for BACE1 over BACE2.
  • Inquiry Price
3-6 months
Size
QTY
NB-360
T121881262857-73-7
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
  • Inquiry Price
10-14 weeks
Size
QTY
TargetMol | Inhibitor Sale
PF-06751979
T124291818339-66-0
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
  • Inquiry Price
10-14 weeks
Size
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β-Secretase Inhibitor IV
T13434797035-11-1
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1, with IC50 values of 15.6 nM and 16.3 nM at BACE-1 concentrations of 2 nM and 100 pM, respectively.
  • Inquiry Price
8-10 weeks
Size
QTY
RO-5508887 HCl
RO-5508887 hydrochloride, 8PU77BD4DA, 310349-35-9
T2024141310349-35-9
RO5508887, also known as RG-7129, is a potent BACE inhibitor with an IC50 of 30 nM for BACE1 and similarly strong activity against BACE2 (IC50=40 nM).
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LY2811376
T26391194044-20-6
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
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LY 2886721 Hydrochloride
T376611262036-49-6
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.
  • Inquiry Price
1-2 weeks
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QTY
BACE1/2-IN-1
T619562671036-34-1
BACE1 2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 values of 0.01 and 0.0053 μM, respectively. It exhibits a lower Pgp efflux ratio, improved passive permeability, and decreased metabolic stability in liver microsomes.
  • Inquiry Price
6-8 weeks
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amg-8718
T625731215868-94-2
AMG-8718 is a selective, orally active and potent BACE1 inhibitor that acts on both BACE1 (IC50: 0.0007 μM) and BACE2 (IC50: 0.005 μM). AMG-8718 significantly reduces CSF and Aβ40 levels in the brain.
  • Inquiry Price
8-10 weeks
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QTY
AZD3839 free base
AZD3839
T67721227163-84-9
AZD3839 free base is a potent and selective BACE1 inhibitor with a Ki of 26.1 nM, demonstrating approximately 14-fold selectivity over BACE2. [Phase 1]
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Umibecestat HCl
CNP520 HCl, CNP-250 HCl, CNP250 HCl, CNP 520 HCl, AMG520 HCl, AMG 520 HCl
T696642365306-62-1 2369750-66-1
Umibecestat HCl (CNP520 HCl) is a highly efficient β-secretase (BACE1 BACE2) inhibitor, lowering Aβ levels in mice and rats, used in Alzheimer's disease research.
  • Inquiry Price
1-2 weeks
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QTY
Verubecestat
MK-8931
T70111286770-55-5
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
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