at2 receptor

BIBS 39 is a novel nonpeptide angiotensin II (AII) receptor antagonist.

CGP-42112 acetate is a potent angiotensin receptor AT2 agonist that inhibits the increase in protein kinase A activity produced by LPS.

Buloxibutid (AT2 receptor agonist C21) is a novel and selective small molecule angiotensin II AT2 receptor agonist, exhibiting Ki values of 0.4 nM and 10 μM for AT2 and AT1 receptors, respectively.

Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.

PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.

Tasosartan (WAY-ANA 756) is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).

AT2 receptorligand-1 (compound 14) is a potent ligand for the angiotensin AT2 receptor, with a Ki value of 4.9 nM. It exhibits high stability in microsomes containing sulfonamide ligands.

CL-329167 (compound 12) is an orally active, competitive angiotensin II receptor antagonist (IC50=6 nM) suitable for hypertension research.

PD 123319 ditrifluoroacetate is a selective, non-peptide angiotensin II type 2 (AT2) receptor antagonist, and PD 123319 ditrifluoroacetate demonstrates potent activity with IC50 values of 34 nM in rat adrenal tissue and 210 nM in rat brain, thereby providing a valuable pharmacological tool for elucidating AT2 receptor function in cardiovascular and renal physiology and supporting research in hypertension and related disorders.

L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol.

Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.

Angiotensin III is an agonist of angiotensin 1 (AT1) and AT2 receptor.

Angiotensin III TFA is an agonist of angiotensin 1 (AT1) and AT2 receptor.

CGP-42112 is an agonist of the Angiotensin-II subtype 2 receptor (AT2 R).

Angiotensin AT2 receptor agonist

Novokinin TFA is a peptide agonist of the angiotensin (AT2) receptor.

Androgen receptor antagonist 4 (Compound AT2) exhibits anticancer activities by potently antagonizing AR transcriptional activity, inhibiting downstream AR target genes, and blocking DHT-induced nuclear translocation of AR. It is an antagonist of the androgen receptor (AR) with an IC50 of 0.15 μM [1].

AT2R antagonist 1 is a highly selective and potent AT2R (angiotensin II AT2 receptor) ligand.AT2R antagonist 1 has a high affinity for AT2R affinity (Ki: 29 nM).AT2R antagonist 1 inhibits common drug metabolizing CYP enzymes and has high stability in human, rat, and mouse liver microsomes.AT2R antagonist 1 has a high affinity for AT2R affinity (Ki: 29 nM).AT2R antagonist 1 has a high affinity for AT2R affinity (Ki: 29 nM). It has high stability in human, rat and mouse liver microsomes.

Cytosporin A is a hexahydrobenzopyran derivative and an angiotensin II receptor antagonist. Its IC50 for AT1 is 25-30 μM, and for AT2 it is 1.5-3 μM.

Cytosporin C is a hexahydrobenzopyran derivative and an angiotensin II receptor inhibitor with strong inhibitory activity against AT2, exhibiting an IC50 of 30-40 μM.

(Sar1,Gly8)-Angiotensin II is a selective AT1 angiotensin II receptor antagonist, with a Ki value of 52 nM for AT2 receptors in rat adrenal glands. It effectively counters the thirst response induced by intracerebroventricular injection of angiotensin II.