anti-carcinogenic

2,5-Dimethyl-3(2H)-furanone (2,5-Dimethyl-2,3-dihydrofuran-3-one) is a non-genotoxic flavoring substance [1].

NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

D-Saccharic acid 1,4-lactone hydrate is a potent β-glucuronidase inhibitor (IC50=48.4 μM) that possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2].

7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates.

Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations.

Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowering activity.

Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.

Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phas

Achillin is a compound isolated from herbs. It may have anti-inflammatory and anti-carcinogenic activities.

Bis(diazoacetyl)butane is a mutagen and traditionally related to radio-mimetic chemical mutagens due to the similarity of appearance of mutagenic action of this mutagen and physical mutagens. It also has anti-tumor and carcinogenic activity.

Almurtide (nor-MDP), a derivative of muramyl dipeptide, exhibits anti-inflammatory and anti-tumor properties. It demonstrates protective effects in mice against infections caused by Pseudomonas aeruginosa when administered intraperitoneally and Candida albicans when administered intravenously. Furthermore, Almurtide has been shown to inhibit the carcinogenic Friend leukemia virus [1] [2] [3].

Rutin (Rutoside) trihydrate, a natural flavonoid glycoside, exhibits multifaceted therapeutic properties, including antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic activities. Additionally, it has demonstrated cardioprotective and neuroprotective effects [1] [2] [3].

β-Boswellic acid (Standard) is a reference standard for research and analysis in studies involving β-Boswellic acid. β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.

Auraptene (Standard) is a reference standard for research and analysis in studies involving Auraptene. Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.

Daidzin (Standard) is a reference standard for research and analysis in studies involving Daidzin. Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.

Rutin trihydrate (Standard) is the standard substance of Rutin trihydrate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Rutin (Rutoside) trihydrate, a natural flavonoid glycoside, exhibits multifaceted therapeutic properties, including antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic activities. Additionally, it has demonstrated cardioprotective and neuroprotective effects .

β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.

3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter.

4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo

Odorine has potent anti-carcinogenic effect by inhibiting both the initiation and promotion stages of two-stage skin carcinogenesis. It was found to inhibit the growth of the vinblastine-resistant KB cells by enhancing the anticancer activity of vinblastine.

DPMI-ω is a dual-specific D-peptide antagonist of the carcinogenic proteins MDM2 and MDMX. When loaded onto gold nanoparticles, DPMI-ω effectively penetrates tumor cells and kills them by reactivating the p53 signaling pathway. It disrupts the p53-MDM2/MDMX complex and inhibits the growth of B16 melanoma while inducing G0/G1 phase cell cycle arrest. Combined with anti-PD1 antibodies, DPMI-ω enhances immunotherapy by amplifying CD3+/CD8+ cytotoxic T cells and inhibiting CD4+/CD25+ regulatory T cells. DPMI-ω is applicable in melanoma research.