adenosine diphosphate

Adenosine 5'-diphosphate (ADP) is a naturally occurring nucleotide derived from the dephosphorylation of ATP. Adenosine 5'-diphosphate is essential for cellular metabolism and induces platelet aggregation.

Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist and exhibits non-selective antagonism at both recombinant and human platelet P2X1 receptors.

Adenosine 5'-diphosphate disodium salt has been shown to inhibit the binding of serotonin (5-hydroxytryptamine) to 5-HT2 receptors, which are present in heart tissue.

Adenosine 5'-diphosphate-15N5 is a 15N-labeled form of Adenosine 5'-diphosphate. This compound, known as a nucleoside diphosphate, is the dephosphorylated product of ATP by ATPases. Adenosine 5'-diphosphate (T1723) induces human platelet aggregation via action on P2T-purinergic receptors and inhibits stimulated adenylate cyclase.

2'(3')-O-(2-Aminoethylcarbamoyl)adenosine-5'-O-diphosphate (2'(3')-AEC-ADP) trisodium is a derivative of Adenosine 5'-diphosphate (ADP).

2-Methylthioadenosine diphosphate trisodium (2-MeS-ADP) is the salt form of 2-Methylthioadenosine diphosphate, a synthetic analog of adenosine diphosphate (ADP), a potent purinergic P2Y receptor agonist that agonizes human P2Y13 at nanomolar levels, mouse P2Y13 and human P2Y12, induces platelet aggregation and morphological changes, and is indicated for neurological and cardiovascular disease studies.

Deoxyadenosine diphosphate sodium is a diphosphate nucleoside featuring deoxyadenosine as its nucleoside component. It plays a role in the synthesis and repair of DNA. Deoxyadenosine diphosphate sodium acts as an inhibitor of polynucleotide phosphorylase, thereby interfering with the polymerization of ADP and CDP.

Linear-benzoadenosine diphosphate is a nucleotide analog.

2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent agonist of purinergic (P2Y) receptors, displaying EC50 values of 19 nM for human P2Y13, 6.2 nM for mouse P2Y13, and 5 nM for human P2Y12. It also has pEC50 values of 8.29 for human P2Y1 and 5.75 for rat P2Y6. 2-MeSADP induces platelet aggregation and morphological changes, while inhibiting the accumulation of cyclic adenosine monophosphate in platelets in the presence of prostaglandin E1.

NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).

D-fructose-1,6-diphosphate (D-fructose-1,6-diphosphate), also known as Fosfructose, is a cytoprotective natural sugar phosphate. It functions by promoting anaerobic glycolysis, which generates adenosine triphosphate (ATP) under ischemic conditions. This compound holds potential for research in cardiovascular ischemia, sickle cell anemia, and asthma.

Adenosine 5'-methylenediphosphate (sodium salt) is also referred to as an inhibitor of ecto-5'-nucleotidase.

2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) is a derivative of Adenosine 5'-diphosphate (ADP) that induces platelet aggregation and inhibits stimulated adenylate cyclase. Additionally, 2-Chloro-ADP can inhibit the nucleotide-binding domain (NBD) of Mortalin with a Ki value of 45.05 μM.

1"-α-Azido-RDPr (Compound 11) is an analogue of adenosine diphosphate ribose, exhibiting inhibitory activity against the macrodomain of SARS-CoV-2 non-structural protein 3 (SARS-CoV-2 NSP3 Mac1), with an IC50 of 30 nM.

8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) sodium salt is an antagonist of cyclic adenosine diphosphate (ADP)-ribose (cADPR) and the TRPM2 ion channel. It can alleviate kidney injury and reduce the expression of caspase-3 and TRPM2.

6-Bn-ADP (N6-benzyl ADP) sodium is a derivative of Adenosine 5'-diphosphate (ADP) that inhibits ATP hydrolysis. It also suppresses the ATPase activity of the proteins Mortalin, Hsc70, and Hsp70, with Ki values of 86.51 μM, 294.5 μM, and 1612 μM, respectively.

NB-3 is an inhibitor of SARM1, the NAD⁺ hydrolase. NB-3 can block the hydrolysis process of NAD⁺ and form a covalent bond with the reaction product adenosine diphosphate ribose (ADPR). The small-molecule ADPR adduct formed by the binding of NB-3 and ADPR shows excellent activity and exerts neuroprotective effects in nerve injury-related scenarios.

BX 048 is an active metabolite of BX 667, an antagonist of P2Y12 adenosine diphosphate receptor for inhibition of platelet aggregation.

SUN-C5174 is a sleective 5-HT2 antagonist (pA2=8.98+/-0.06). SUN C5174 showed a marked inhibitory effect on the platelet aggregation induced by serotonin in combination with collagen and adenosine diphosphate (ADP) in canine or human platelet-rich plasma

Adenosine 3',5'-diphosphate sodium salt is an inhibitor of hydroxysteroid sulfotransferases, which are adenine nucleotides containing a phosphate group at the 3' and 5' positions of the pentose ribose.Adenosine 3',5'-diphosphate (sodium salt) is the product of 3'-phosphoadenosine 5'-phosphosulfonate (PAPS), a cofactor of sulfotransferases (SULTs). diphosphate disodium is the product of 3'-phosphoadenosine 5'-phosphosulfonate (PAPS), a cofactor for sulfotransferases (SULTs), which has been used to study the kinetic properties and structure of SULTs.

Adenosine 5'-methylenediphosphate is an inhibitor of ecto-5'-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5'-monophosphate , adenosine 5'-diphosphate , or adenosine 5'-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5'-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.2,3It increases tumor infiltration of CD3+CD8+T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 μg/mouse.4 1.Bruns, R.F.Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosineNaunyn Schmiedebergs Arch. Pharmacol.315(1)5-13(1980) 2.Braganhol, E., Tamajusuku, A.S.K., Bernardi, A., et al.Ecto-5′-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell lineBiochim. Biophys. Acta1770(9)1352-1359(2007) 3.Shali, S., Yu, J., Zhang, X., et al.Ecto\5′\nucleotidase (CD73) is a potential target of hepatocellular carcinomaJ. Cell Physiol.234(7)10248-10259(2018) 4.Forte, G., Sorrentino, R., Montinaro, A., et al.Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanomaJ. Immunol.189(5)2226-2233(2021)

Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

Adenosine 5'-diphosphate sodium salt (ADP sodium salt) is an adenine nucleotide that is phosphorylated into ATP by ATPase. This phosphorylation is a key part of cellular homeostatis as it allows for energy storage and is involved in nucleic acid metabolism. ADP affects platelet activation through its interaction with ADP receptors P2Y1, P2Y12 and P2X1. Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP).