mitf — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2P2810	Methyl Linoleate	Linoleic acid methyl ester,Telfairic Acid methyl ester	Antioxidant
	Methyl Linoleate (Telfairic Acid methyl ester) linoleate has antioxidant activity.		Antioxidant
T4028	ML329		TRP/TRPV Channel
	ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.		TRP/TRPV Channel
T77743	TT-012		Others
	TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the g...		Others
TP2487	Oligopeptide-68 Acetate	Oligopeptide-68 Acetate(1206525-47-4 Free base)	Others
	Oligopeptide-68 Acetate is a peptide. It is a novel whitening ingredient that mimics the binding of TGF-β to cell surface receptors to reduce induced and hereditary pigmentation by inhibiting MITF intramolecular channels...		Others
T3676	Sesamol	1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol	Apoptosis , AMPK
	Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 sig...		Apoptosis , AMPK
TN2246	Swertiajaponin		Tyrosinase
	Swertiajaponin possesses antimicrobial activity.		Tyrosinase
T13762	Luteolin 7-sulfate		Others
	Luteolin 7-sulfate, derived from the marine plant Phyllospadix iwatensis Makino, suppresses TYR gene expression by intervening in a signaling pathway involving the cAMP-responsive element binding protein (CREB) and micro...		Others
TN4179	Haginin A		ERK , Tyrosinase , Akt
	Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activation, MITF, and also by the subsequent downregulation of t...		ERK , Tyrosinase , Akt
TN4468	(-)-Lyoniresinol 9'-O-glucoside		Others
	(-)-Lyoniresinol 9'-O-glucoside is a natural product from Phyllostachys heterocycla MITF.		Others
T75506	6-Acetylnimbandiol
	6-Acetylnimbandiol (6-O-Acetylnimbandiol), a non-cytotoxic tyrosinase inhibitor (IC 50 = 69.85 μM), effectively inhibits melanin production and MITF expression, making it valuable for melanoma research [1].
TMA0003	Trans-caffeic acid		cAMP , Tyrosinase
	Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyr...		cAMP , Tyrosinase
T76597	Prolylserine
	Prolylserine, a dipeptide, acts as a melanogenesis inhibitor in Mel-Ab cells by reducing microphthalmia-associated transcription factor (MITF) and tyrosinase expression, inducing phosphorylation of ERK, but not affecting...
T79996	N,N′-Diferuloylputrescine		Melanocortin Receptor
	N,N′-Diferuloylputrescine acts as a pigment inhibitor, showing a 57% reduction in pigmentation. It also considerably diminishes the protein expression of MITF and displays potent antioxidant properties as a radical scave...		Melanocortin Receptor
T75535	5-epi-Arvestonate A
	5-epi-Arvestonate A, a sesquiterpenoid extracted from Seriphidium transiliense whole plants, enhances melanogenic production by stimulating MITF and tyrosinase family gene transcription. Additionally, it suppresses IFN-γ...
TN4489	Manassantin A		ERK , cAMP , TNF , NF-κB , MAPK , COX , HIF , Prostaglandin Receptor , JNK , STAT
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibitio...