Oleaceae

Cholesterol is the primary sterol in mammals, accounting for approximately 20–25% of the plasma membrane structure. It plays a key role in regulating membrane fluidity, permeability, and protein function. As an endogenous agonist of estrogen-related receptor α (ERRα), cholesterol is widely involved in metabolic regulation and serves as a precursor for the synthesis of hormones and bile acids. It is commonly used in experimental models of hyperlipidemia.

Nuezhenidic acid is isolated from Ligustrum lucidum and has the ability to inhibit influenza A virus.

Oleuropein is an antioxidant polyphenol isolated from olive leaf.

Methyl jasmonate ((-)-Methyl jasmonate) is a hormone involved in plant signaling, inducing oxidative stress and accumulation of secondary metabolites in plant cells and organ cultures, and regulating the biosynthesis of other plant hormones. Methyl jasmonate induces plant defense responses against Andean lupin insects. Methyl jasmonate has anti-inflammatory activity.

(±)-Jasmonic acid (trans-Jasmonic acid) is a compound found in grapevine inflorescences and fruits with pro-aging activity, inhibiting chlorophyll levels in green and yellowing barley leaf segments, suppressing rice seedling elongation, and participating in biogenic amine chemical coupling through decarboxylation with both aliphatic and aromatic α-amino acids.

Cornoside is a natural phenolic glycoside that inhibits rat lens aldose reductase (AR) activity, reducing oxidative stress and inflammation in diabetic complications.

Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a marked inhibitory effect on S.aureus proliferation. It increased the level of Nrf2/ARE, and HO-1, inhibit the formation of ROS, cytochrome c release, activation of caspase-3 and 9, and suppressed the up-regulation of Bax.

Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling, thereby suppressing IL-1β-induced chondrocyte inflammation. It exerts anti-inflammatory effects in a rat model of osteoarthritis (OA).

1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.

Oleonuezhenide is a natural product from Chinese formula Ligustrum lucidum, exerts neuroprotective effects and also considered as treatment of osteoporosis.

Fraxin (Fraxoside) is a glucoside of fraxetin.

Oleanonic acid (3-Ketooleanolic Acid) is relatively non-toxic, hepatoprotective, and exhibits antitumor and andantiviral properties.

Jasmine lactones are volatile and odor-active compounds with aromatic properties.Jasmolactone, delta- is also used in the synthesis of pharmaceuticals, and a polyjasmolactone copolymer serves as a reactive oxygen species-modulated coupler and drug delivery system.

GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1.

6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.

Fraxinol is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 5, 7-dimethoxy-2h-chromen-2-one. It is generated by cyp1a2, cyp2a6, cyp2b6, cyp2c9, cyp2c19, and cyp2e1 enzymes via an aromatic-hydroxylation-of-fused-be

Benzyl acetate, a constituent of Jasmine, as well as the essential oils of ylang-ylang and neroli.

7-Methylcoumarin with strong hepatoprotective activity.

Methyl dihydrojasmonate (Kharismal) is an ester and a diffusive aroma compound, with the smell vaguely similar to jasmine. In racemic mixtures the odor is floral and citrus while epimerized mixtures exhibit a dense fatty floral odor with odor recognition thresholds of 15 parts per billion.

Ligupurpuroside A is a naturally occurring bioactive compound isolated from Ligustrum robustum. Ligupurpuroside A acts as a competitive inhibitor of lipase, thereby reducing lipid breakdown. This natural lipase inhibitor has potential applications in metabolic research, particularly in the study of obesity and lipid metabolism regulation.

Jasmoside is a natural product from Jasminum mesnyi.

Ligustroside is a natural product of phenolic glycosides from olive plants, which has antioxidant and anti-inflammatory activities. Ligustroside can up-regulate the mRNA expression of SIRT1, CREB1 and GPx1 in SH-SY5Y-APP695 cells. At the same time, the production of nitric oxide (NO) was significantly inhibited in RAW264.7 macrophages stimulated by lipopolysaccharide (LPS). Ligustroside has potential application value in cardiovascular and metabolic diseases related research.

Isojasminin is a natural product for research related to life sciences. The catalog number is TN4301 and the CAS number is 135378-08-4.

6'-O-Cinnamoyl-8-epikingisidic acid is a natural product derived from Ligustrum lucidum.