Loganiaceae

Loganetin, a non-toxic natural product, shows antibacterial activity against multidrug-resistant Gram-negative infections.

Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitory effects on melanogenesis.

Vomicine is a natural product from Strychnos nux-vomica, the S. nux-vomica extracts show antihyperglycemic activity in experimental animals.

7-Deoxy-10-hydroxyloganetin is a natural product for research related to life sciences. The catalog number is TN3223 and the CAS number is 76267-48-6.

Indole-2-carboxylic acid is an indole carboxylic acid compound with multi-target biological activity, exhibiting neuroprotective, antiviral, and antioxidant properties. Indole-2-carboxylic acid is a competitive antagonist at the glycine site of the NMDA receptor (Ki = 15 μM). Indole-2-carboxylic acid specifically inhibits the potentiating effect of glycine on NMDA-gated currents, blocking the neurotoxicity caused by excessive NMDA receptor activation, and can be used in research on the treatment of neurodegenerative diseases and cerebral ischemic injury. Indole-2-carboxylic acid is also an HIV-1 integrase inhibitor; it interferes with the integration of viral DNA into the host genome and can be used in the development of anti-HIV drugs.

3-Indolyl acetate is an indole ester compound widely found in various plant tissues. As an important signaling molecule in plants, 3-indolyl acetate regulates a variety of physiological processes, including growth and defense against pathogens, and is used in plant physiology research. It is also utilized in enzyme activity assays, microbial identification, and pharmaceutical research and development.

Gardneramine has a mild central depressive effect. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor plays a main role.