Ericaceae

Asebogenin is a natural product isolated from the leaves of Pieris japonica that exhibits antifungal activity, inhibits GPVI-induced platelet responses, and suppresses NET formation induced by pro-inflammatory stimuli.

Ursonic Acid (TOS-BB-0966) belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibitor.

Ardisiacrispin A (Deglucocyclamin) has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM, it could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule.Ardisiacrispin(A+B) exhibit prominent abilities to inhibit the proliferation of HL-60 cells by blocking the cell cycle at S phase and inducing apoptosis.

Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in vascular relaxation. At the dose of 1-40 μM, epithelial growth factor receptor signaling and estrogen receptor α expression were inhibited, which was associated with apoptosis and autophagy. Delphinidin chloride regulates JAK/STAT3 and MAPKinase signaling. Delphinidin also inhibited the histone acetyltransferase activity of p300/CBP (IC50 was about 30 μM).

Malvidin-3-glucoside chloride (Oenin chloride) has antioxidant activity, alone is not oxidized in the presence of grape polyphenol oxidase. Malvidin-3-O-glucoside chloride's color stabilization at a higher pH can be explained by self-aggregation of the flavylium cation and copigmentation with the Z-chalcone form.

Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.

Keracyanin chloride (Cyanidin 3-rutinoside chloride), an anthocyanin compound, exhibits antioxidant properties and effectively prevents the formation of malonaldehyde in oxidized calf thymus DNA, underlining its potential in reducing oxidative damage.

Luteolinidin chloride is a natural product. It is a potent CD38 inhibitor which can protect the heart against I/R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo.

Cyanidin-3-O-galactoside chloride (Ideain chloride), extracted from hawthorn pericarp (EPHF), possesses antioxidant activity and is applicable in obesity research.

Delphinidin 3-glucoside chloride (Delphinidin-3-O-glucoside chloride) is a dietary phenolic substance found in Hibiscus sabdariffa extracts. Delphinidin 3-glucoside chloride has antioxidant activity, induces pro-apoptotic effects in B-cell chronic lymphocytic leukemia (B CLL), inhibits EGFR, and inhibits platelet aggregation. Delphinidin 3-glucoside chloride has antitumor activity, and is known to inhibit platelet aggregation by modulating pAKT/IRF1/IRF1/IRF1/IRF1/IRF1/IRF1/IRF1/IRF1/IRF1. Delphinidin 3-glucoside chloride has anti-tumor activity and acts by regulating the pAKT/IRF1/HOTAIR pathway.

Antibacterial; anti-inflammatory

Primin is a natural product stored in trichomes on the leaves and stems of Primula obconica, exhibiting antimycobacterial and strong antineoplastic actions.

Pterostilbene is extracted from Pterocarpus indicus.

1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3. Farrerol inactivates KEAP-1 or act

Ardisicrenoside A is a naturally occurring saponin that is toxic to human gastric KATO-III adenocarcinoma cells (IC50 = 14.5 μM).

Arbutin (p-Arbutin)(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the formation of melanin.

Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.

1. Rhodojaponin II correlates pretty well with cardiotoxicity.

1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodojaponin III induces a certain linkage

Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, which was the source of cytoprotecti

Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.

Azaleatin is a natural product from Rhododendron simsii. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for type-2 diabetes and obesity studies.

α-Arbutin (4-hydroxyphenyl-D-lucopyranoside) is a synthetic and functional active ingredient for skin lightening.

Ledol ((+)-Ledol) is a naturally occurring sesquiterpene with potential biological activities such as antioxidant, anti-inflammatory, xanthine oxidase inhibition and uric acid reduction.