Ailanthus

Ailanthone (AIL) is a natural compound derived from the tree Ailanthus altissima and has anti-hepatocellular carcinoma (HCC) properties. It can induce G0/G1 phase cell cycle arrest by downregulating the expression of cyclins and CDKs, while upregulating the expression of p21 and p27. Additionally, Ailanthone is a potent androgen receptor (AR) inhibitor, capable of inhibiting both the full-length androgen receptor (IC50: 69 nM) and constitutively active splice variants (IC50: 309 nM).

Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.

1-Methoxycarbonyl-β-carboline (1-Methoxycarbonyl-beta-carboline) is an alkaloid from Ailanthus altissima.

Canthin-6-one (NSC 103003)is an alkaloid isolated from Allium neapolitanum with antibacterial activity and inhibitory effect against Mycobacterium tuberculosis.

Chaparrinone, a bittersweet analog from Ailanthus altissima (Mill.), has antimalarial, antitumor, and antiviral activities and has been used in the study of tobacco mosaic virus infections and SARS virus infections.

Stigmast-4-ene-3beta,6beta-diol possesses marked inhibitory activity against 12-O- -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.

2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.

5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 uM versus doxorubicine with IC50 = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosi

Quassin, neoquassin and picrasinoside B are insecticide quassinoids.

Rehmaglutin D is a natural product of Ailanthus, Simaroubaceae. The catalog number is TN4904 and the CAS number is 103744-84-9. Rehmaglutin D can be used as a reference standard.

Ocotillone has potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that are without hemolytic activity, whereas it has weak antimicrobial activity against Gram-positive bacteria and fungi. Ocotillone shows only

20,24-Dihydroxydammar-25-en-3-one is a natural product for research related to life sciences. The catalog number is TN2794 and the CAS number is 75069-59-9.

1-Hydroxy-9-medroxycanthin-6-one is a natural product for research related to life sciences. The catalog number is TN2537 and the CAS number is 622408-85-9.

Shinjulactone L is a natural product of Ailanthus, Simaroubaceae. The catalog number is TN5006 and the CAS number is 4283-49-2. Shinjulactone L can be used as a reference standard.

4,9-Dimethoxycanthin-6-one is a natural product from Ailanthus altissima.

9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably through interfering with Ca2+ mobilization.9-Hydroxycanthin-6-one inhibits Wnt signaling through the activation of GSK3β independent of CK1α.

9-Methoxycanthin-6-one-N-oxide shows cytotoxic activity against a panel of cell lines comprising a number of human cancer cell types.