STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.

Cat. No.	Product name	CAS No.	Purity
T5317	Cridanimod	38609-97-1	98%
T5317	Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/...
T36983	Cyclic-di-GMP disodium	2222132-40-1	98%
T36983	Cyclic-di-GMP disodium is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, ...
T11035	DiABZI STING agonist-1 (Tautomerism)	2138498-18-5	98%
T11035	diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respe...
T60000	2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-3,4-dihydro-3-oxo-N-(phenylmethyl)-	702662-64-4	98%
T60000	2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-3,4-dihydro-3-oxo-N-(phenylmethyl)- is a STING modulator with antibacterial and antiviral...
T5674	H-151	941987-60-6	98%
T5674	H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
T9204	N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide	727699-84-5	98%
T9204	N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide was reported as a STING inhbiitor, which inhibited the activation of the STING signal pat...
T5154	C-176	314054-00-7	98%
T5154	C-176 is a strong, covalent mouse STING inhibitor
T9028	STING-IN-2	346691-38-1	98%
T9028	C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflam...
T8328	STING agonist-1	702662-50-8	98%
T8328	STING agonist-1 is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
T6919	Omaveloxolone	1474034-05-3	98%
T6919	Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T8655	SR-717	2375421-09-1	98%
T8655	SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor acti...
T7081	CCCP	555-60-2	98%
T7081	CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
T9029	STING-IN-3	2244881-69-2	98%
T9029	C-171 is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation...
T9137	SN-011	2249435-90-1	98%
T9137	GUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl ana...
T7329	C-178	329198-87-0	98%
T7329	C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells...
T8798	MSA-2	129425-81-6	98%
T8798	MSA-2 is a potent and orally available non-nucleotide STING agonist.
T9554	SN-008	2249106-01-0	98%
T9554	SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
T5516	DiABZI STING agonist-1 trihydrochloride	2138299-34-8	98%
T5516	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
T13015	STING agonist-4	2138300-40-8	98%
T13015	STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
T13613	ChX710	2438721-44-7	98%
T13613	ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequenc...