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STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79199 F-CRI1 98%
F-CRI1
F-CRI1, a potent STING agonist with a dissociation constant (K d) of 40.62 nM, is an 18F-labeled radioactive probe employed for visualizing STING in the tumor mi...
T79313 BI 7446 2767011-00-5 98%
BI 7446
BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in...
T79320 Antitumor agent-114 2757762-91-5 98%
Antitumor agent-114
Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models,...
T79730 LB244 98%
LB244
LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependen...
T79779 SAP-04 98%
SAP-04
SAP-04 is a potent, orally active STING agonist exhibiting significant immunomodulatory effects appropriate for cancer therapy [1].
T81082 STING-IN-7 899947-07-0 98%
STING-IN-7
STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of ...
T82760 C-di-IMP disodium 98%
C-di-IMP disodium
C-di-IMP disodium, a STING agonist, is utilized in tumor research [1].
T83047 Anti-inflammatory agent 65 98%
Anti-inflammatory agent 65
Anti-inflammatory agent 65 (compound 29), a Hederagonic acid derivative, exhibits potent activity by inhibiting nitric oxide (NO) release, nuclear translocation ...
T75011 STING-IN-5 2920064-17-9 98%
STING-IN-5
STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO)...
T10065 2',3'-cGAMP 1441190-66-4 98%
2',3'-cGAMP
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3...
T5317 Cridanimod 38609-97-1 99.96%
Cridanimod
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/...
T36983 Cyclic-di-GMP disodium 2222132-40-1 99.93%
Cyclic-di-GMP disodium
Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm fo...
T11035 DiABZI STING agonist-1 (Tautomerism) 2138498-18-5 99.72%
diABZI STING agonist-1 (Tautomerism)
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 13...
T10065L 2',3'-cGAMP sodium 2734858-36-5 99.71%
2',3'-cGAMP sodium
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding co...
T60000 STING (WT/R232) activity regulator 126 702662-64-4 99.61%
STING (WT/R232) activity regulator 126
STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.
T5674 H-151 941987-60-6 99.52%
H-151
H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING ...
T9204 SN-001 727699-84-5 99.51%
SN-001
SN-001 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.
T5154 C-176 314054-00-7 99.40%
C-176
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor
T5516 DiABZI STING agonist-1 trihydrochloride 2138299-34-8 99.18%
diABZI STING agonist-1 trihydrochloride
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
T74809 STING agonist-30 2951078-67-2 99.04%
STING agonist-30
STING agonist-30 is a potent STING agonist that triggers STING-dependent immune activation.STING agonist-30 shows broad-spectrum inhibitory effects against a var...
F-CRI1
T79199
F-CRI1, a potent STING agonist with a dissociation constant (K d) of 40.62 nM, is an 18F-labeled radioactive probe employed for visualizing STING in the tumor mi...
BI 7446
T79313
BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in...
Antitumor agent-114
T79320
Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models,...
LB244
T79730
LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependen...
SAP-04
T79779
SAP-04 is a potent, orally active STING agonist exhibiting significant immunomodulatory effects appropriate for cancer therapy [1].
STING-IN-7
T81082
STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of ...
C-di-IMP disodium
T82760
C-di-IMP disodium, a STING agonist, is utilized in tumor research [1].
Anti-inflammatory agent 65
T83047
Anti-inflammatory agent 65 (compound 29), a Hederagonic acid derivative, exhibits potent activity by inhibiting nitric oxide (NO) release, nuclear translocation ...
STING-IN-5
T75011
STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO)...
2',3'-cGAMP
T10065
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3...
Cridanimod
T5317
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/...
Cyclic-di-GMP disodium
T36983
Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm fo...
diABZI STING agonist-1 (Tautomerism)
T11035
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 13...
2',3'-cGAMP sodium
T10065L
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding co...
STING (WT/R232) activity regulator 126
T60000
STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.
H-151
T5674
H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING ...
SN-001
T9204
SN-001 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.
C-176
T5154
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor
diABZI STING agonist-1 trihydrochloride
T5516
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
STING agonist-30
T74809
STING agonist-30 is a potent STING agonist that triggers STING-dependent immune activation.STING agonist-30 shows broad-spectrum inhibitory effects against a var...
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TargetMol