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STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.
Cat. No. Product name CAS No. Purity Chemical Structure
T5317 Cridanimod 38609-97-1 98%
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/...
T36983 Cyclic-di-GMP disodium 2222132-40-1 98%
Cyclic-di-GMP disodium is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, ...
T11035 DiABZI STING agonist-1 (Tautomerism) 2138498-18-5 98%
diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respe...
T60000 2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-3,4-dihydro-3-oxo-N-(phenylmethyl)- 702662-64-4 98%
2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-3,4-dihydro-3-oxo-N-(phenylmethyl)- is a STING modulator with antibacterial and antiviral...
T5674 H-151 941987-60-6 98%
H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
T9204 N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide 727699-84-5 98%
N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide was reported as a STING inhbiitor, which inhibited the activation of the STING signal pat...
T5154 C-176 314054-00-7 98%
C-176 is a strong, covalent mouse STING inhibitor
T9028 STING-IN-2 346691-38-1 98%
C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflam...
T8328 STING agonist-1 702662-50-8 98%
STING agonist-1 is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
T6919 Omaveloxolone 1474034-05-3 98%
Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T8655 SR-717 2375421-09-1 98%
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor acti...
T7081 CCCP 555-60-2 98%
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
T9029 STING-IN-3 2244881-69-2 98%
C-171 is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation...
T9137 SN-011 2249435-90-1 98%
GUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl ana...
T7329 C-178 329198-87-0 98%
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells...
T8798 MSA-2 129425-81-6 98%
MSA-2 is a potent and orally available non-nucleotide STING agonist.
T9554 SN-008 2249106-01-0 98%
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
T5516 DiABZI STING agonist-1 trihydrochloride 2138299-34-8 98%
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
T13015 STING agonist-4 2138300-40-8 98%
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
T13613 ChX710 2438721-44-7 98%
ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequenc...
Cridanimod
T5317
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/...
Cyclic-di-GMP disodium
T36983
Cyclic-di-GMP disodium is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, ...
diABZI STING agonist-1 (Tautomerism)
T11035
diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respe...
2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-3,4-dihydro-3-oxo-N-(phenylmethyl)-
T60000
2H-1,4-Benzothiazine-6-carboxamide, 4-[(2-chloro-6-fluorophenyl)methyl]-3,4-dihydro-3-oxo-N-(phenylmethyl)- is a STING modulator with antibacterial and antiviral...
H-151
T5674
H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide
T9204
N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide was reported as a STING inhbiitor, which inhibited the activation of the STING signal pat...
C-176
T5154
C-176 is a strong, covalent mouse STING inhibitor
STING-IN-2
T9028
C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflam...
STING agonist-1
T8328
STING agonist-1 is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
Omaveloxolone
T6919
Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
SR-717
T8655
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor acti...
CCCP
T7081
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
STING-IN-3
T9029
C-171 is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation...
SN-011
T9137
GUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl ana...
C-178
T7329
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells...
MSA-2
T8798
MSA-2 is a potent and orally available non-nucleotide STING agonist.
SN-008
T9554
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
diABZI STING agonist-1 trihydrochloride
T5516
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
STING agonist-4
T13015
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
ChX710
T13613
ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequenc...
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