T63208 |
Aβ-IN-1
|
2766509-32-2
|
98%
|
|
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
|
T10532 |
BI-1408
|
2231075-94-6
|
98%
|
|
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
|
T31987 |
Gossypolone
|
4547-72-2
|
98%
|
|
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
|
T9641 |
Aβ42-IN-2
|
1914989-80-2
|
98%
|
|
Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].
|
T71534 |
CIA-1 hcl(452087-38-6 Free base)
|
1049691-47-5
|
98%
|
|
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of p...
|
T14683 |
BMS-983970
|
1584713-87-0
|
98%
|
|
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
|
TP1540 |
Jagged-1 (188-204)
|
219127-21-6
|
98%
|
|
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
|
T15184 |
E 2012
|
870843-42-8
|
98%
|
|
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at ...
|
T6202 |
DAPT
|
208255-80-5
|
98%
|
|
DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
|
T16294 |
NGP555
|
1304630-27-0
|
98%
|
|
NGP555 is a modulator of γ-secretase.
|
T6935 |
Nirogacestat
|
1290543-63-3
|
98%
|
|
PF-03084014 (PF-3084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
|
T11358 |
Gamma-secretase modulator 1
|
1172637-87-4
|
98%
|
|
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
|
T11178L |
ELN318463 racemate
|
851599-82-1
|
98%
|
|
ELN318463 racemate is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
|
T22678 |
3,5-Bis(4-nitrophenoxy)benzoic acid
|
173550-33-9
|
98%
|
|
The compound is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
|
T12246 |
CB-103
|
218457-67-1
|
98%
|
|
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
|
T6135 |
YO-01027
|
209984-56-5
|
98%
|
|
YO-01027 is a potent γ-secretase inhibitor.
|
T6870 |
L-685458
|
292632-98-5
|
98%
|
|
L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
|
T9422 |
Fosciclopirox
|
1380539-06-9
|
98%
|
|
Fosciclopirox, the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract f...
|
T4077 |
PE859
|
1402727-29-0
|
98%
|
|
PE859 is a potent inhibitor of both tau and Aβ aggregation.
|
T35566 |
RBPJ Inhibitor-1
|
2682114-39-0
|
98%
|
|
RBPJ Inhibitor-1 (RIN1), the RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell p...
|