Gamma-secretase

Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43[verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch, ErbB4, E-cadherin, N-cadherin, ephrin-B2, or CD44.

Cat. No.	Product name	CAS No.	Purity
T63208	Aβ-IN-1	2766509-32-2	98%
T63208	Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
T10532	BI-1408	2231075-94-6	98%
T10532	BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
T31987	Gossypolone	4547-72-2	98%
T31987	Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
T9641	Aβ42-IN-2	1914989-80-2	98%
T9641	Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].
T71534	CIA-1 hcl(452087-38-6 Free base)	1049691-47-5	98%
T71534	CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of p...
T14683	BMS-983970	1584713-87-0	98%
T14683	BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
TP1540	Jagged-1 （188-204）	219127-21-6	98%
TP1540	This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
T15184	E 2012	870843-42-8	98%
T15184	E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at ...
T6202	DAPT	208255-80-5	98%
T6202	DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
T16294	NGP555	1304630-27-0	98%
T16294	NGP555 is a modulator of γ-secretase.
T6935	Nirogacestat	1290543-63-3	98%
T6935	PF-03084014 (PF-3084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
T11358	Gamma-secretase modulator 1	1172637-87-4	98%
T11358	gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
T11178L	ELN318463 racemate	851599-82-1	98%
T11178L	ELN318463 racemate is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid	173550-33-9	98%
T22678	The compound is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
T12246	CB-103	218457-67-1	98%
T12246	CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
T6135	YO-01027	209984-56-5	98%
T6135	YO-01027 is a potent γ-secretase inhibitor.
T6870	L-685458	292632-98-5	98%
T6870	L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
T9422	Fosciclopirox	1380539-06-9	98%
T9422	Fosciclopirox, the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract f...
T4077	PE859	1402727-29-0	98%
T4077	PE859 is a potent inhibitor of both tau and Aβ aggregation.
T35566	RBPJ Inhibitor-1	2682114-39-0	98%
T35566	RBPJ Inhibitor-1 (RIN1), the RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell p...