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Gamma-secretase

Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43[verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch, ErbB4, E-cadherin, N-cadherin, ephrin-B2, or CD44.
Cat. No. Product name CAS No. Purity Chemical Structure
T63208 Aβ-IN-1 2766509-32-2 98%
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
T10532 BI-1408 2231075-94-6 98%
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
T31987 Gossypolone 4547-72-2 98%
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
T9641 Aβ42-IN-2 1914989-80-2 98%
Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].
T71534 CIA-1 hcl(452087-38-6 Free base) 1049691-47-5 98%
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of p...
T14683 BMS-983970 1584713-87-0 98%
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
TP1540 Jagged-1 (188-204) 219127-21-6 98%
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
T15184 E 2012 870843-42-8 98%
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at ...
T6202 DAPT 208255-80-5 98%
DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
T16294 NGP555 1304630-27-0 98%
NGP555 is a modulator of γ-secretase.
T6935 Nirogacestat 1290543-63-3 98%
PF-03084014 (PF-3084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
T11358 Gamma-secretase modulator 1 1172637-87-4 98%
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
T11178L ELN318463 racemate 851599-82-1 98%
ELN318463 racemate is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
T22678 3,5-Bis(4-nitrophenoxy)benzoic acid 173550-33-9 98%
The compound is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
T12246 CB-103 218457-67-1 98%
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
T6135 YO-01027 209984-56-5 98%
YO-01027 is a potent γ-secretase inhibitor.
T6870 L-685458 292632-98-5 98%
L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
T9422 Fosciclopirox 1380539-06-9 98%
Fosciclopirox, the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract f...
T4077 PE859 1402727-29-0 98%
PE859 is a potent inhibitor of both tau and Aβ aggregation.
T35566 RBPJ Inhibitor-1 2682114-39-0 98%
RBPJ Inhibitor-1 (RIN1), the RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell p...
Aβ-IN-1
T63208
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells ...
BI-1408
T10532
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
Gossypolone
T31987
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
Aβ42-IN-2
T9641
Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].
CIA-1 hcl(452087-38-6 Free base)
T71534
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of p...
BMS-983970
T14683
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
Jagged-1 (188-204)
TP1540
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epiderma...
E 2012
T15184
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at ...
DAPT
T6202
DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
NGP555
T16294
NGP555 is a modulator of γ-secretase.
Nirogacestat
T6935
PF-03084014 (PF-3084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
gamma-secretase modulator 1
T11358
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
ELN318463 racemate
T11178L
ELN318463 racemate is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
3,5-Bis(4-nitrophenoxy)benzoic acid
T22678
The compound is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
CB-103
T12246
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
YO-01027
T6135
YO-01027 is a potent γ-secretase inhibitor.
L-685458
T6870
L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
Fosciclopirox
T9422
Fosciclopirox, the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract f...
PE859
T4077
PE859 is a potent inhibitor of both tau and Aβ aggregation.
RBPJ Inhibitor-1
T35566
RBPJ Inhibitor-1 (RIN1), the RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell p...
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