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Gamma-secretase

Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43[verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch, ErbB4, E-cadherin, N-cadherin, ephrin-B2, or CD44.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T39905 Legumain inhibitor 1 2361157-34-6 98.14%
Legumain inhibitor 1
Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.
T71534 CIA-1 hcl(452087-38-6 Free base) 1049691-47-5 98%
CIA-1 hcl(452087-38-6 Free base)
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of p...
T14683 BMS-983970 1584713-87-0 98%
BMS-983970
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
TP1540 Jagged-1 (188-204) 219127-21-6 98%
Jagged-1 (188-204)
Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epi...
T11718 JI051 2234281-75-3 98%
JI051
JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcr...
T76698 Rovalpituzumab 1613313-01-1 SDS-PAGE:95% SEC-HPLC:95%
Rovalpituzumab
Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used to synthesize antibody-active molecule conjug...
T76788 Demcizumab 1243262-17-0 SDS-PAGE:95% SEC-HPLC:95%
Demcizumab
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent Notch pathway inhibitor. Demcizumab is effective in multiple cancer models, bo...
T14680 BMS-906024 1401066-79-2 99.87%
BMS-906024
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour...
T15184 E 2012 870843-42-8 99.83%
E 2012
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at ...
T6202 DAPT 208255-80-5 99.81%
DAPT
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces ...
T16773 Ro 90-7501 293762-45-5 99.80%
Ro 90-7501
Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phospho...
T16294 NGP555 1304630-27-0 99.77%
NGP555
NGP555 is a modulator of γ-secretase.
T6935 Nirogacestat 1290543-63-3 99.77%
Nirogacestat
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
T11358 Gamma-secretase modulator 1 1172637-87-4 99.75%
gamma-secretase modulator 1
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
T11178L ELN318463 racemate 851599-82-1 99.73%
ELN318463 racemate
ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
T22678 3,5-Bis(4-nitrophenoxy)benzoic acid 173550-33-9 99.71%
3,5-Bis(4-nitrophenoxy)benzoic acid
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like pep...
T12246 CB-103 218457-67-1 99.69%
CB-103
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
T62263 γ-Secretase modulator 13 1353570-40-7 99.68%
γ-Secretase modulator 13
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease an...
T6135 YO-01027 209984-56-5 99.63%
YO-01027
YO-01027 (DBZ) is a potent γ-secretase inhibitor.
T9422 Fosciclopirox 1380539-06-9 99.60%
Fosciclopirox
Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urina...
Legumain inhibitor 1
T39905
Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.
CIA-1 hcl(452087-38-6 Free base)
T71534
CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety of p...
BMS-983970
T14683
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
Jagged-1 (188-204)
TP1540
Jagged-1 (188-204)is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epi...
JI051
T11718
JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcr...
Rovalpituzumab
T76698
Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used to synthesize antibody-active molecule conjug...
Demcizumab
T76788
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent Notch pathway inhibitor. Demcizumab is effective in multiple cancer models, bo...
BMS-906024
T14680
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour...
E 2012
T15184
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at ...
DAPT
T6202
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces ...
Ro 90-7501
T16773
Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phospho...
NGP555
T16294
NGP555 is a modulator of γ-secretase.
Nirogacestat
T6935
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
gamma-secretase modulator 1
T11358
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
ELN318463 racemate
T11178L
ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
3,5-Bis(4-nitrophenoxy)benzoic acid
T22678
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like pep...
CB-103
T12246
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
γ-Secretase modulator 13
T62263
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease an...
YO-01027
T6135
YO-01027 (DBZ) is a potent γ-secretase inhibitor.
Fosciclopirox
T9422
Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urina...
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TargetMol