y705

Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.

Chlorfenprop-methyl is a biochemical.

STAT3-IN-53 (Compound L20) is a STAT3 inhibitor with a dissociation constant (Kd) of 6.16 μM. It binds directly to the SH2 domain of STAT3, inhibiting phosphorylation at the Y705 site without affecting total STAT3 protein levels. STAT3-IN-53 downregulates the transcription and expression of cyclin-D1 and c-Myc, induces cell cycle arrest, and promotes apoptosis. Additionally, STAT3-IN-53 exhibits anticancer activity against colorectal cancer.

STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705, which induces apoptosis and inhibits tumor cell growth and metastasis.STAT3-IN-13 can be used to study breast cancer and liver cancer. The study of breast cancer and hepatocellular carcinoma.

STAT3-IN-24, a cell-permeable (PpYLKTK-mts) peptide inhibitor, obstructs the recruitment of STAT3 to Jak2 and inhibits the phosphorylation of Y705, thereby preventing STAT3 dimerization and nuclear translocation [1].