vitamin b 3

Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP.

Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.

Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes. Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC. Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.

Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.

Niacin (Standard) is the analytical standard of Niacin (Vitamin B3). As an essential water-soluble nutrient and a primary precursor to the coenzymes NAD+ and NADP+, it plays a fundamental role in cellular energy metabolism, gene expression, and the regulation of apoptosis. Niacin acts as an agonist for the GPR109A receptor, modulating lipid profiles and exerting anti-inflammatory effects. It is a cornerstone molecule in research concerning cardiovascular health, metabolic homeostasis, and the mechanisms of aging.

Nicotinic Acid-[13C3,15N](Vitamin B3-[13C3,15N]) (Standard) is a reference standard of Nicotinic Acid-[13C3,15N](Vitamin B3-[13C3,15N]) intended for quantitative analysis, quality control, and related biochemical research applications.

Nicotinamide-13C6 (Standard) is a reference standard of Nicotinamide-13C6 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-13C6 is a 13C-labeled form of Nicotinamide. As a vitamin B3, Nicotinamide plays a crucial role in cellular physiology by supporting NAD+ redox homeostasis and serving as a substrate for a class of enzymes that catalyze non-redox reactions. It is also known as a SIRT1 inhibitor.

Vitamin B3-13C6) (Standard) is a reference standard of Vitamin B3-13C6) intended for quantitative analysis, quality control, and related biochemical research applications.

Nicotinamide-15N,13C3 (Standard) is a reference standard of Nicotinamide-15N,13C3 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-15N,13C3 is a form of nicotinamide labeled with 13C and 15N. Nicotinamide, a vitamin B3, is crucial in cellular physiology by maintaining NAD+ redox balance and supplying NAD+ as a substrate for enzymes catalyzing non-redox reactions. Nicotinamide also acts as an SIRT1 inhibitor.

Vitamin B3-D4 (Standard) is a reference standard of Vitamin B3-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.

Methyl 3-(2,4-dihydroxyphenyl)propionate is a novel vitamin E derivative that inhibits tyrosinase, which is an antioxidant and inhibits UV-B-induced hyperpigmentation, with potential whitening effects.

Biotin Sodium (Vitamin B7) is a water-soluble B vitamin acting as a coenzyme for five carboxylases critical in human metabolism, including the synthesis of fatty acids, isoleucine, and valine, as well as gluconeogenesis. It is essential for cell growth, fatty acid production, and the metabolism of fats and amino acids [1] [2] [3].