uv-induced

Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.

Benzyl salicylate (NSC 6647), a salicylic acid derivative, is protective against cisplatin-induced apoptosis in LLC-PK1 cells and also inhibits LPS-induced NO production.

TPO-L is a photoinitiator used in 3D printing resins, facilitating two-photon induced polymerization. The two-photon absorption cross-section spectrum of Lucirin TPO-L exhibits a peak of 1.2 GM at 610 nm. Although the two-photon absorption cross-section is relatively small, Lucirin TPO-L demonstrates a high polymerization quantum yield.

I2959, widely known as Irgacure 2959, is a photoinitiator extensively used for ultraviolet light-induced photocrosslinking of hydrogels in biomedical applications and is particularly utilized in combination with carboxymethylcellulose (CMA) hydrogels as a bioink for bio 3D printing applications; furthermore, I2959 is recognized for its high radical generation efficiency under UV exposure but also exhibits concentration-dependent cytotoxicity to rapidly dividing cell lines.

Methyl 3-(2,4-dihydroxyphenyl)propionate is a novel vitamin E derivative that inhibits tyrosinase, which is an antioxidant and inhibits UV-B-induced hyperpigmentation, with potential whitening effects.

8-Chloro caffeine binds to adenosine receptors with a Ki of 30 µM. It enhances UV-induced chromosomal aberrations in the Cl-I type Chinese hamster embryo lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine.

Seletinoid G is a retinoic acid receptor (RAR) agonist that can repair damaged connective tissue in aging skin and inhibit UV-induced collagen deficiency in young skin. It is applicable in studies related to skin aging and photoaging.

1-(1-Naphthyl)piperazine is a modulator of 5-HT receptors, acting both as a 5-HT2A receptor antagonist and a 5-HT1A receptor agonist, with a human 5-HT6 receptor binding constant (Ki) of 120 nM. It partially inhibits forskolin-stimulated adenylate cyclase activity in bovine substantia nigra and can suppress UV radiation-induced immunosuppression. Additionally, 1-(1-Naphthyl)piperazine induces S-phase cell cycle delay, apoptosis, and increases reactive oxygen species (ROS) levels, leading to the inhibition of MNT-1 cell proliferation. This compound is utilized in melanoma research.

Lotifazole (F 1686) is a non-steroidal anti-inflammatory drug. At low doses, it specifically inhibits delayed-type hypersensitivity reactions without relying on the prostaglandin synthesis inhibition pathway. At higher doses, Lotifazole significantly alleviates carrageenan-induced paw edema in rats, UV-induced erythema in guinea pigs, and pleurisy. Lotifazole can be utilized in the study of T cell-mediated diseases.

Ecamsule disodium is a versatile UVA filter compound commonly employed in the formulation of sunscreen products. Its primary role is to mitigate the potential harm posed by solar radiation through the prevention of various biological repercussions induced by UV exposure. These include the inhibition of pyrimidine dimer formation, the reduction of p53 protein accumulation, and the downregulation of collagenase 2 expression.

33-BCRP inhibitor is a compound that blocks the action of breast cancer resistance protein (BCRP), enhancing the susceptibility of mitoxantrone-resistant H460/MX20 lung cancer cells to the cytotoxic effects of mitoxantrone, both individually and when combined with UV radiation. Additionally, it enhances the sensitivity of KB-C2 epidermal carcinoma cells, which overexpress P-glycoprotein (P-gp) or multidrug resistance protein (MDR), to colchicine-induced apoptosis. Furthermore, at a concentration of 5 µM, it boosts the intracellular accumulation of mitoxantrone in H460/MX20 cells.

2,4-Di-tert-butylphenol-D19 is the deuterated form of 2,4-Di-tert-butylphenol. 2,4-Di-tert-butylphenol (T9600) (2,4-DTBP) is an orally active RXRα activator with anti-inflammatory and antioxidant properties, capable of inducing apoptosis in tumor cells. It activates the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. Additionally, it exhibits antiviral and antifungal activities and may inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol (T9600) serves as an intermediate in the production of antioxidants and UV stabilizers and is used in the manufacture of pharmaceuticals and fragrances.

Afzelin (Standard) is a reference standard for research and analysis in studies involving Afzelin. Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.

Rhodoxanthin is a carotenoid that exhibits antioxidant properties by scavenging free radicals and inhibiting lipid peroxidation. It holds potential for research into oxidative stress-related diseases [such as UV-induced skin damage].

Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.

Afzelin (Kaempferol-3-O-rhamnoside) exhibits several cellular activities such as DNA-protective, antibacterial, antioxidant, anti-inflammatory, and UV-absorbing properties, potentially protecting human skin from UVB-induced damage through a combination of UV-absorbing and cellular actions. Afzelin mitigates mitochondrial damage, promotes mitochondrial biogenesis, and reduces levels of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.

Odoriflavene has antioxidant activity, and it also shows inhibition effects on the decrease of glutathione level of rat lens induced by UV irradiation. Odoriflavene shows cytotoxic activity against a SH-SY5Y cell line in vitro.

Tsugaric acid A significantly inhibits superoxide anion formation in fMLP/CB-stimulated rat neutrophils and protects human keratinocytes against damage induced by ultraviolet B (UV B) light, indicating that tsugaric acid A can safeguard keratinocytes from photodamage.

T4EndonucleaseV is a bifunctional DNA glycosylase that exhibits both DNA N-glycosylase and AP lyase activities. It is capable of repairing cyclobutane pyrimidine dimers induced by ultraviolet (UV) radiation in DNA.

4-Amino-TEMPO is employed as a spin label to detect free radicals and the damage they cause. It mimics the activity of superoxide dismutase and can easily penetrate cells, thus safeguarding them against oxidative damage induced by H2O2. Moreover, 4-Amino-TEMPO demonstrates significant radioprotective properties, effectively shielding DNA from oxidative stress damage caused by UV irradiation by maintaining a positive charge. Additionally, 4-Amino-TEMPO serves as a highly selective oxidation catalyst and is extensively used in the development of various specialty chemicals, including fragrances and pesticides.