udp

UDP-rhamnose (UDP-L-rhamnose) is a sugar nucleotide widely found in plants and animals and is used in the synthesis of pectin in cell walls.UDP-rhamnose is recognised in fungi and is used in the synthesis of quercetin.

UDP-3-O-acyl-GlcNAc diammonium functions as a metabolite in E. coli, playing a critical role in the biosynthesis pathway of 3-deoxy-D-manno-octulosonate (KDO) [1].

UDP-GlcNAc is a fundamental component and precursor of bacterial peptidoglycan. Additionally, UDP-GlcNAc acts as an agonist for the P2Y14 receptor, which can inhibit the formation of cAMP.

UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) Tris functions as a metabolite in E. coli, participating in the biosynthesis pathway of 3-deoxy-D-manno-octulosonate (KDO) [1].

Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction. Uridine-5'-diphosphate disodium salt also acts as an antagonist of P2Y14.

Tunicamycin is a mixture of antibiotics that inhibit N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT). Tunicamycin has antitumor activity, as well as anti-bacterial, anti-fungal, and anti-viral activity.

Uridine 5′-diphosphoglucose disodium salt (UDP-Glucose sodium salt) is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It is an agonist of the P2Y14 receptor (EC50 = 0.35 μM) and can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.

Uridine diphosphate glucose (UDP-glucose) is a pyrimidine nucleotide sugar, serving as a precursor for oligosaccharides, polysaccharides, glycoproteins, and glycolipids containing glucose. It is a key intermediate in carbohydrate metabolism and participates in numerous enzymatic reactions, acting as a P2Y14 agonist.

Hecogenin (Hocogenin), a steroid saponin derived from Agave sisalana, serves as a specific inhibitor for human UDP-glucuronosyltransferases. Notably, it exhibits a broad range of pharmacological activities, such as anti-inflammatory, antifungal, and gastroprotective effects[1].

Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a precursor of many plant cell wall polysaccharides and is required for the production of seed mucilage.Uridine diphosphate glucuronic acid ammonium is a precursor of pathogenic fungi. ammonium is a key metabolite for pod polysaccharide synthesis in the pathogenic fungus Cryptococcus neoformans.

UDP-xylose, a natural product isolated from Cryptococcus laurentii (NRRL Y-1401), serves as a sugar donor in the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides across plants, vertebrates, and fungi [1] [2].

UDP-xylose disodium is a compound that can be isolated from Cryptococcus laurentii and is a sugar donor that can be used for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi.

UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine), an E. coli metabolite, is involved in the 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway [1].

UDP-g acid is a sugar used in the production of polysaccharides and is an intermediate in the biosynthesis of ascorbic acid

Salicylamide (2-Hydroxybenzamide) is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In the over-the-counter pain remedies, Salicylamide is used in combination with both aspirin and caffeine.

Estrone-3-Glucuronide sodium is a coupled metabolite of estrone, which is formed in the liver by UDP-glucuronyltransferase through glucuronide coupling.

Cholesterol glucuronide is an endogenous lipid metabolite generated by UDP-gluconyltransferase in the liver.

CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is a variant inhibitor of UDP-GlcNAc 2-epimerase, the activated form of sialic acid, which is widely found in animals and is involved in the metabolism of organisms.

α-D-Glucose-1-phosphate sodium hydrate (Glucose-1-phosphate sodium hydrate) is an intermediate in glycogen metabolism and a precursor in UDP-glucose biosynthesis.

Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, with smaller chain lengths predominant during development and longer chain lengths predominant in mature cells. They accumulate in the lysosome of patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency. Sulfatides are also located in pancreatic β-cells and inhibit insulin release from isolated rat pancreatic islet cells, suggesting a potential role in diabetes. Sulfatides can induce inflammation in glia in vitro and certain sulfatides, such as C24:1 3'-sulfo-galactosylceramide, can induce an immune response in vitro in mouse splenocytes. Sulfatides (bovine) (sodium salt) is a mixture of isolated bovine sulfatides.

Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.

Propofol β-D-Glucuronide is the major inactive metabolite of isoproterenol sulfate (a short-acting anesthetic), mediated by UDP-glucuronosyltransferase (UGT), and can be used to study sleep deprivation (SD).

1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 value

1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.